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They can hydroxylate and oxidize phenolic molecules and are mostly known for producing melanins that confer protection against photo induced damage. TYRs are also thought to play an important role in the \u2018latch mechanism\u2019, where high concentrations of phenolic compounds inhibit oxidative decomposition of organic biomass and subsequent CO\n                    <jats:sub>2<\/jats:sub>\n                    release, especially relevant in wetland environments. In the present study, we describe two TYRs,\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr1 and\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr2, from halophilic bacterium\n                    <jats:italic>Hahella<\/jats:italic>\n                    sp. CCB MM4 previously isolated at Matang mangrove forest in Perak, Malaysia. The structure of\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr1 was determined by X\u2010ray crystallography at a resolution of 1.9\u2009\u00c5 and represents an uncharacterized group of prokaryotic TYRs as demonstrated by a sequence similarity network analysis. The genes encoding the enzymes were cloned, expressed, purified and thoroughly characterized by biochemical methods.\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr1 was able to self\u2010cleave its lid\u2010domain (LID) in a protease independent manner, whereas the LID of\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr2 was essential for activity and stability. Both enzymes showed variable activity in the presence of different metals, surfactants and NaCl, and were able to oxidize lignin constituents. The high salinity tolerance of\n                    <jats:italic>Hc<\/jats:italic>\n                    Tyr1 indicates that the enzyme can be an efficient catalyst in the habitat of the host.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13906","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T06:41:35Z","timestamp":1728456095000},"page":"2038-2058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of two bacterial tyrosinases from the halophilic bacterium\n                    <i>Hahella<\/i>\n                    sp.\n                    <scp>CCB MM<\/scp>\n                    4 relevant for phenolic compounds oxidation in wetlands"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-4271","authenticated-orcid":false,"given":"Gustavo","family":"de Almeida Santos","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Biotechnology and Food Science NMBU \u2013 Norwegian University of Life Sciences  \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea N. 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