{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:33:16Z","timestamp":1793025196448,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19KK0176"],"award-info":[{"award-number":["19KK0176"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K12192"],"award-info":[{"award-number":["20K12192"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    We investigated potential germline\u2010specific radiosensitive biomarkers in the testes of large Japanese field mice (\n                    <jats:italic>Apodemus speciosus<\/jats:italic>\n                    ) exposed to low\u2010dose\u2010rate (LDR) radiation after the Fukushima accident. Fukushima wild mice testes were analysed via RNA\u2010sequencing to identify genes differentially expressed in the breeding and non\u2010breeding seasons when compared to controls. Results revealed significant changes during the breeding season, with\n                    <jats:italic>Lsp1<\/jats:italic>\n                    showing a considerable upregulation, while\n                    <jats:italic>Ptprk<\/jats:italic>\n                    and\n                    <jats:italic>Tspear<\/jats:italic>\n                    exhibited significant reductions. Conversely, in the non\u2010breeding season,\n                    <jats:italic>Fmo2<\/jats:italic>\n                    and\n                    <jats:italic>Fmo2<\/jats:italic>\n                    (highly similar) were significantly upregulated in radiation\u2010exposed Fukushima mice. qPCR analysis results were consistent with transcriptome sequencing, detecting\n                    <jats:italic>Lsp1<\/jats:italic>\n                    and\n                    <jats:italic>Ptprk<\/jats:italic>\n                    regulation in the testes of Fukushima mice. While differences in gene expression were observed, these do not imply any causal association between the identified biomarkers and chronic LDR exposure, as other factors such as the environment and developmental age may contribute. This study provides valuable insights into the reproductive biology is affected by environmental radiation and highlights the value of assessing the effects of chronic LDR radiation exposure on testicular health in wild mice.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13927","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T12:40:22Z","timestamp":1733143222000},"page":"296-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident"],"prefix":"10.1002","volume":"15","author":[{"given":"Syun","family":"Tokita","sequence":"first","affiliation":[{"name":"Graduate School of Science and Technology Niigata University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Risk 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