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Isosorbide di\u2010(methyl fumarate) (IDMF), a novel derivative of DMF, was synthesized to circumvent this adverse reaction and unlock the potential of topical delivery, which could be useful for treating psoriasis in the subpopulation of psoriatic MS patients, as well as in the general population. Here, we compared its therapeutic potential of this non\u2010sensitizing derivative with DMF and its therapeutic version Diroximel in three skin\u2010 and neuroinflammation models: the lck\u2010GFP zebrafish, activated BV\u20102 murine microglia and human T\u2010lymphocyte Jurkat cell line. The results provide a comparative evaluation of the bioactivity of these three related chemical entities in models relevant to skin and neuroinflammation and expose several therapeutic advantages unique to IDMF.<\/jats:p>","DOI":"10.1002\/2211-5463.13969","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T02:51:04Z","timestamp":1737168664000},"page":"754-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative activity of dimethyl fumarate derivative\n                    <scp>IDMF<\/scp>\n                    in three models relevant to multiple sclerosis and psoriasis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yulin","family":"He","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition The Hong Kong Polytechnic University  Hung Hom China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition The Hong Kong Polytechnic University  Hung Hom China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovani","family":"Quijas","sequence":"additional","affiliation":[{"name":"Sunny BioDiscovery Inc.  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