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However, the roles of two biomarkers of Alzheimer's disease (AD), amyloid \u03b2\u2010peptide (A\u03b2) and tau, and that of calcium pumps which are involved in the fine\u2010tuning of calcium homeostasis, are poorly understood in astrocytes. In this study, we showed that treating astrocytoma U\u2010251 cells with a cocktail of cytokines significantly increased plasma membrane Ca<jats:sup>2+<\/jats:sup>\u2010ATPase (PMCA) activity and expression levels of the four PMCA isoforms. Moreover, treatment of cells with A\u03b21\u201042 or tau induced a similar upregulation of PMCA activity and isoform expression levels as cytokines. These effects support the close association of A\u03b2 and tau with inflammation. 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