{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:10Z","timestamp":1772117830958,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Despite the recent scientific advancements, pancreatic cancer remains the seventh leading cause of cancer\u2010related mortality. Pancreatic cancer progression is closely associated with inflammation, and we previously showed that short hairpin RNA\u2010mediated knockdown of sST2 expression, a soluble decoy receptor for the proinflammatory molecule interleukin\u201033 (IL\u201033), in mouse Panc02 pancreatic cancer cells reduced malignant growth following pancreatic (orthotopic) implantation. Furthermore, this growth suppression was accompanied by decreased tumor angiogenesis, reduced expression of the neutrophil chemoattractant CXCL3, and a lower number of tumor\u2010associated neutrophils (TANs). In contrast to previous results, in this study, we showed that IL\u201033\u2010dependent tumor growth and pulmonary metastasis occurred following subcutaneous (ectopic) implantation of sST2\u2010knockdown cells. This was associated with a decrease in the levels of\u00a0the anti\u2010inflammatory molecule adiponectin and the number of GLUT4\u2010positive cancer\u2010associated adipocytes, as well as an increase in I\u03baB\u03b1 phosphorylation levels,\n                    <jats:italic>Cxcl3<\/jats:italic>\n                    expression, and the accumulation of infiltrating CD206\n                    <jats:sup>+<\/jats:sup>\n                    protumor N2 TANs. Taken together, these results suggest that Panc02 cell\u2010derived sST2 differentially affects malignant growth in the tumor microenvironment depending on the implantation site.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70099","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T12:04:14Z","timestamp":1754136254000},"page":"2031-2044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Downregulation of\n                    <scp>sST2<\/scp>\n                    , a decoy receptor for interleukin\u201033, enhances subcutaneous tumor growth in murine pancreatic cancer cells"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-2257","authenticated-orcid":false,"given":"Miho","family":"Akimoto","sequence":"first","affiliation":[{"name":"Department of Biochemistry Teikyo University School of Medicine  Tokyo 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