{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:20:07Z","timestamp":1788402007328,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001420"],"award-info":[{"award-number":["UL1 TR001420"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA012197"],"award-info":[{"award-number":["P30 CA012197"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM119227"],"award-info":[{"award-number":["R01 GM119227"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM135179"],"award-info":[{"award-number":["R35 GM135179"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG\u201019\u2010150\u201001\u2010LIB"],"award-info":[{"award-number":["RSG\u201019\u2010150\u201001\u2010LIB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Anthracycline\u2010induced cardiotoxicity remains a major limitation in cancer therapy, affecting long\u2010term cardiovascular health in survivors. Dietary nitrate supplementation has shown cardioprotective effects in preclinical models of doxorubicin (Dox)\u2010induced and ischemia\u2013reperfusion injury, but it is unclear whether nitrate and\/or nitrite (NOx) would have adverse effects on the anticancer efficacy of the drug. To evaluate Dox efficacy against triple\u2010negative breast cancer (TNBC) in the presence of dietary nitrate and nitrite, tumor\u2010bearing BALB\/c mice (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20095 mice per group, 10 mice total) were treated with four weekly intravenous doses of Dox with or without NOx supplementation of their drinking water. Cardiac tissue from the NOx\u2010treated mice exhibited less fibrosis and lower levels of 4\u2010hydroxynonenal\u2010modified proteins, a marker of lipid oxidation and oxidative stress. Tumor sizes varied, but most regressed by the final Dox dose. Importantly, NOx supplementation did not compromise the antitumor efficacy of Dox nor did it promote pulmonary metastasis; instead, a trend toward fewer metastatic lesions was observed. These findings support the potential clinical use of dietary nitrate and nitrite as adjuncts to Dox treatment to mitigate cardiotoxicity without impairing anticancer outcomes.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70139","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:30:02Z","timestamp":1763645402000},"page":"584-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary nitrate and nitrite protect against doxorubicin\u2010induced cardiac fibrosis and oxidative protein damage in tumor\u2010bearing mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Rama D.","family":"Yammani","sequence":"first","affiliation":[{"name":"Department of Biochemistry Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Molecular Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nildris","family":"Cruz\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Surgery Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Molecular Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Center for Redox Biology and Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Physics Wake Forest University  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Kim\u2010Shapiro","sequence":"additional","affiliation":[{"name":"Center for Redox Biology and Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Department of Physics Wake Forest University  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Soto\u2010Pantoja","sequence":"additional","affiliation":[{"name":"Department of Surgery Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Center for Redox Biology and Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Cardiovascular Sciences Center Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Department of Cancer Biology Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Comprehensive Cancer Center Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-7328","authenticated-orcid":false,"given":"Leslie B.","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Center for Redox Biology and Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"},{"name":"Comprehensive Cancer Center Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00795.2008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-024-02131-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103066"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102338"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214558024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13131151"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1398108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.30824\/2212\u201012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq370"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01257.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4544"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15192"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.12.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071683"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm954"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.03.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_166.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6954"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2013.11.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801336105"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.46"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:23:36Z","timestamp":1773077016000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/2211-5463.70139"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.70139","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.70139\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}