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TNBC has limited targeted therapies and poor survival due to late diagnosis and metastasis. Dendrimers are precise nanostructures with a three\u2010dimensional globular architecture designed to target the negatively charged membranes of cancer cells. This study evaluated the anticancer potential of two novel core\u2013shell polycationic polyurea (PURE) dendrimers, PURE\n                    <jats:sub>G4<\/jats:sub>\n                    \u2010OEI\n                    <jats:sub>48<\/jats:sub>\n                    and PURE\n                    <jats:sub>G4<\/jats:sub>\n                    \u2010OCEI\n                    <jats:sub>24<\/jats:sub>\n                    , targeting BC cell membranes. Both dendrimers selectively interacted with TNBC cells, inducing apoptosis, necroptosis, and ferroptosis.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , they reduced tumor volume in HCC1806 xenografts, with PURE\n                    <jats:sub>G4<\/jats:sub>\n                    \u2010OEI\n                    <jats:sub>48<\/jats:sub>\n                    showing no toxicity, while PURE\n                    <jats:sub>G4<\/jats:sub>\n                    \u2010OCEI\n                    <jats:sub>24<\/jats:sub>\n                    induced mild hepatic toxicity. These results suggest PURE dendrimers are promising TNBC treatments, with further modifications needed to enhance efficacy and reduce toxicity.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70144","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:40:58Z","timestamp":1773679258000},"page":"944-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting\n                    <scp>TNBC<\/scp>\n                    : core\u2013shell polycationic polyurea dendrimers with inherent anticancer activity"],"prefix":"10.1002","volume":"16","author":[{"given":"Adriana","family":"Cruz","sequence":"first","affiliation":[{"name":"iBB\u2010Institute for Bioengineering and Biosciences, and Associate Laboratory i4HB\u2010Institute for Health and Bioeconomy Instituto Superior T\u00e9cnico  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Abreu","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto  Lisbon 1099\u2010023 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Mendes","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto  Lisbon 1099\u2010023 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Freitas\u2010Dias","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto  Lisbon 1099\u2010023 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto  Lisbon 1099\u2010023 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Silva","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Ramalho","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saudade","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"iNOVA4Health, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisbon Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto  Lisbon 1099\u2010023 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco D. 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