{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:09:49Z","timestamp":1780304989736,"version":"3.54.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced \u03b12\u20106sialo mucin O\u2010glycans in human tracheobronchial epithelial cells, which mediated the killing of U937 macrophages. By extending this study, we focus here on whether altered glycans induced by alcohol in human airway epithelial cells can promote adhesion of\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>Kp<\/jats:italic>\n                    ) and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>Sp<\/jats:italic>\n                    ). We have found that exposure of human tracheal epithelial cells to alcohol also induces high mannose N\u2010glycans terminated with \u03b13mannose and increases adhesion of\n                    <jats:italic>Kp<\/jats:italic>\n                    , which is inhibited by \u03b1methylmannoside or aldehyde dehydrogenase 2 activator 1. Further, the \u03b12\u20106sialo mucin O\u2010glycans induced by alcohol in human tracheal epithelial cells also enhance the adhesion of\n                    <jats:italic>Sp<\/jats:italic>\n                    , which is inhibited by ovine submaxillary mucin or aldehyde dehydrogenase 2 activator 1. We conclude that alcohol induces altered glycans in human airway epithelial cells, which increase the risk of bacterial pneumonia by compromising immune function and promoting the adhesion of\n                    <jats:italic>Kp<\/jats:italic>\n                    and\n                    <jats:italic>Sp<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70188","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:41:51Z","timestamp":1766385711000},"page":"1142-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alcohol\u2010induced altered glycans in human tracheal epithelial cells promote bacterial adhesion"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-2865","authenticated-orcid":false,"given":"Pi\u2010Wan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of 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