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However, it remains poorly characterized which treatments lead to a senescent state. Our findings identify Talazoparib, a PARP1 inhibitor, as the most potent inducer of senescence in nonsmall cell lung carcinoma cell lines among a variety of PARP1 inhibitors. In the absence of PARP1, no senescence phenotype was observed, thus demonstrating that PARP1 is necessary for the induction of senescence in nonsmall cell lung carcinoma cells exposed to Talazoparib. This enzyme is also required to induce an increase in cell death with the addition of\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.googleadservices.com\/pagead\/aclk?sa=L&amp;ai=DChcSEwjw9M6_vM-MAxWPlWgJHc2uN9kYABAAGgJ3Zg&amp;co=1&amp;gclid=EAIaIQobChMI8PTOv7zPjAMVj5VoCR3NrjfZEAAYASAAEgI60vD_BwE&amp;ohost=www.google.com&amp;cid=CAASJuRobBSFmSgMV40UF3cJtnTYUGKOrFf6zTiWoYLfjE5EkmHK_cdB&amp;sig=AOD64_0F22lno3zby63cLZy8a_FdVJ4Vlg&amp;adurl=&amp;q=\">Navitoclax (ABT\u2010263)<\/jats:ext-link>\n                    , a senolytic drug. As senescence has been shown to have several protumoral effects, these results demonstrate the importance of determining which anticancer therapies induce a senescence phenotype as it could lead to not only treatment failure but alsodrug combinations targeting this pathway to further enhance anticancer treatment efficacy.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70206","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:00:10Z","timestamp":1771563610000},"page":"1370-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>PARP<\/scp>\n                    inhibitors induce a senescence phenotype in non\u2010small cell lung carcinoma cell lines"],"prefix":"10.1002","volume":"16","author":[{"given":"Camille","family":"Huart","sequence":"first","affiliation":[{"name":"Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life 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