{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:47:43Z","timestamp":1791899263513,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    The malaria parasite\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    exports a large number of proteins to the human host cell, including members of the J\u2010domain protein (JDP) family. In other systems, JDPs stimulate the ATPase activity of HSP70 and direct client protein interactions. Three exported\n                    <jats:italic>Pf<\/jats:italic>\n                    JDP are highly homologous yet appear to have divergent roles. We examined the ability of isolated J\u2010domains from these proteins to stimulate the ATPase activity of\n                    <jats:italic>Pf<\/jats:italic>\n                    HSP70\u2010X and human\n                    <jats:italic>Hs<\/jats:italic>\n                    HSP70 and\n                    <jats:italic>Hs<\/jats:italic>\n                    HSC70.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays demonstrate that all domains stimulate the ATPase activity of each HSP70 tested. While overall stimulation was broadly comparable, differences were observed between individual\n                    <jats:italic>Pf<\/jats:italic>\n                    JDP\u2013HSP70 pairings. Our findings support a model in which\n                    <jats:italic>the parasite systematically<\/jats:italic>\n                    exports JDPs to exploit the host's chaperone power.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70207","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:14:31Z","timestamp":1769854471000},"page":"1293-1304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Promiscuous stimulation of\n                    <scp>HSP70 ATPase<\/scp>\n                    activity by parasite\u2010derived J\u2010domains"],"prefix":"10.1002","volume":"16","author":[{"given":"Julian","family":"Barth","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology Justus Liebig University  Giessen 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