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An important phenomenon in this regard is the presence of a differentiated secondary structure for chain fragments of identical sequence\u2014referred to as chameleons. In the present work, individual chain fragments were shown to constitute components of a system with specific physicochemical properties of the overall structure, adapting the secondary structure to the superior role assigned to the protein. The proteins (domains) represent the construction with a centrally located hydrophobic core and a polar surface (described by 3D Gauss function) representing a favourable arrangement in contact with water\u2014the standard environment for the activity of most proteins. The fuzzy oil drop model (FOD\u2010M), which takes into account the presence of a non\u2010water environment for the active protein, was used to assess this condition. The proteins present in the ChSeq database are the object of analysis. The criterion for qualifying a pair of proteins for the analysis presented herein is the presence of a structuring\u2014a hydrophobicity distribution consistent with a 3D Gaussian distribution representing a micelle\u2010like system. The analysis shows that an appropriate secondary structure is not an aim by itself, but a means to achieve a hydrophobicity distribution appropriate for the status represented by the structural unit with its defined biological activity. The mathematical model for\n                    <jats:italic>in silico<\/jats:italic>\n                    simulation of protein folding process as environment dependent is also presented.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70214","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:18:13Z","timestamp":1771395493000},"page":"1340-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chameleon sequences reveal structural effects in proteins representing micelle\u2010like distribution of hydrophobicity"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-9099","authenticated-orcid":false,"given":"Irena","family":"Roterman","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Telemedicine Jagiellonian University \u2013 Medical College  Krakow 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