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Here we report that ER\u03b1\u03947 predicted poor survival in luminal A type breast cancer from TCGA data. ER\u03b1\u03947 occurred more frequently in luminal type breast cancer, with expression inversely correlating with\n                    <jats:italic>ESR1<\/jats:italic>\n                    expression. Functionally, ER\u03b1\u03947\u2010expressing MCF\u20107 cells were found to have lower death rates at the expense of reduced growth and migration, while also being responsive to estrogen deprivation. Furthermore, molecular dynamics simulation showed that estradiol can bind to ER\u03b1\u03947. Our study indicated that ER\u03b1\u03947 might serve as a potential prognostic marker in Luminal A type breast cancer and has different functions from those of canonical ER\u03b1\u2010expressing cells.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70215","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:21:39Z","timestamp":1771395699000},"page":"1400-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exon 7 splicing of\n                    <scp>ER\u03b1<\/scp>\n                    predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer"],"prefix":"10.1002","volume":"16","author":[{"given":"Long Wai","family":"Tsui","sequence":"first","affiliation":[{"name":"Division of Life Science Hong Kong University of Science &amp; Technology  Hong Kong 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