{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:59:42Z","timestamp":1790881182849,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP256f0137001"],"award-info":[{"award-number":["JP256f0137001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K16236"],"award-info":[{"award-number":["JP22K16236"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Loss of Kif26b function causes renal agenesis or hypoplasia in mice, and a KIF26B mutation resulting in deletion of the C\u2010terminal region has been identified in a human patient with a congenital kidney disorder. However, the role of this region during kidney development is unclear; thus, to investigate this, we generated mice lacking the C\u2010terminal region of KIF26B (Kif26b\u2010C) using CRISPR\/Cas9. Homozygous Kif26b\u2010C mice showed bilateral renal agenesis, resembling Kif26b knockout mice. Histological analysis revealed loss of the nephrogenic zone and impaired nephron progenitor condensation at embryonic day 18.5.\n                    <jats:italic>In situ<\/jats:italic>\n                    hybridization showed reduced Gdnf in the metanephric mesenchyme and reduced Wnt11 in ureteric buds, indicating disruption of the Gdnf\u2010Wnt11 signaling loop. These findings suggest a key role for the KIF26B C\u2010terminal region in kidney morphogenesis.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70260","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:40:57Z","timestamp":1779122457000},"page":"1925-1933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The C\u2010terminal region of\n                    <scp>KIF26B<\/scp>\n                    is indispensable for nephron progenitor condensation and kidney formation in mice"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-0733","authenticated-orcid":false,"given":"Yuta","family":"Yamamura","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sako","family":"Keisuke","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Koshino","sequence":"additional","affiliation":[{"name":"Department of 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Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kanazawa University  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