{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:59:47Z","timestamp":1790881187168,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    The effects of time\u2010restricted feeding (TRF) on immune responses during bacterial infection are not well\u2010studied. Here, we subjected mice (6\u20138\u2009weeks, male) to 8\u2009h of TRF for 30\u2009days and then infected them with a low dose of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb) H37Rv. During the first 15\u2009days, TRF improved glucose tolerance with marginal weight loss. However, global serum and liver metabolomics alongside liver proteomics indicated that TRF perturbed fatty acid biosynthesis and degradation, steroid hormone biosynthesis, and tyrosine metabolism. Together, these results indicate that TRF potentially affected the distribution and functionality of host immune cells. TRF mice had similar mycobacterial burdens in lungs and spleen at 21\u2009days postinfection but had significantly lower CD3\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells in bone marrow and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells in both bone marrow and lungs. Ultimately, we show that TRF induced changes in amino acid and lipid metabolism persist during Mtb infection.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70263","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:43:33Z","timestamp":1780580613000},"page":"1944-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010restricted feeding prior to\n                    <i>Mycobacterium tuberculosis<\/i>\n                    infection reduces tissue\n                    <scp>CD4<\/scp>\n                    + T\u00a0cells with limited impact on bacterial clearance"],"prefix":"10.1002","volume":"16","author":[{"given":"Ashish","family":"Gupta","sequence":"first","affiliation":[{"name":"Translational Health Group International Centre for Genetic Engineering and Biotechnology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Yadav","sequence":"additional","affiliation":[{"name":"Translational Health Group International Centre for Genetic Engineering and Biotechnology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5723-6845","authenticated-orcid":false,"given":"Subhasmita","family":"Das","sequence":"additional","affiliation":[{"name":"Clinical Proteomics Laboratory BRIC\u2010Institute of Life Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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