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We investigated the cardioprotective effects of the selective cluster of differentiation\u201036 receptor (CD36) modulator azapeptide MPE\u2010298 in a mouse model of myocardial ischemia\u2013reperfusion. Given before reperfusion, a single intravenous dose of azapeptide MPE\u2010298 reduced infarct size by 44% of the area\u2010at\u2010risk and transiently decreased left ventricular long\u2010chain fatty acids (LCFA) accumulation, independently of saturation status. Metabolomic profiling identified changes in amino acids that may fuel the tricarboxylic acid cycle and provide substrates for glutathione\u2010dependent antioxidant defense. Gene expression analysis showed transient modulation of oxidative stress and inflammation\u2010associated genes in both heart and adipose tissue. 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