{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:40:47Z","timestamp":1782895247524,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006324","name":"National Institute for Basic Biology","doi-asserted-by":"publisher","award":["19\u2010341"],"award-info":[{"award-number":["19\u2010341"]}],"id":[{"id":"10.13039\/501100006324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006324","name":"National Institute for Basic Biology","doi-asserted-by":"publisher","award":["20\u2010337"],"award-info":[{"award-number":["20\u2010337"]}],"id":[{"id":"10.13039\/501100006324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006324","name":"National Institute for Basic Biology","doi-asserted-by":"publisher","award":["21\u2010204"],"award-info":[{"award-number":["21\u2010204"]}],"id":[{"id":"10.13039\/501100006324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["22H00953"],"award-info":[{"award-number":["22H00953"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"abstract":"<jats:p>\n                    Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) encompasses liver conditions not caused by alcohol, including metabolic dysfunction\u2010associated steatohepatitis (MASH), which involves inflammation and fibrosis, with rising global prevalence. While research to explore MASLD\/MASH prevention or cure has largely relied on rodent models, ethical concerns regarding animal welfare have prompted the exploration of alternatives. This study examines the application of a recently developed medaka fish MASH\/MASLD model to assess the impact of food components on liver pathology. Medaka were divided into groups and fed for 12\u2009weeks with either a normal diet (ND), a high\u2010fat diet (HFD), or HFD supplemented with\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010oryzanol (Ory). Liver samples were analyzed morphologically, histologically, and biochemically using GC\/MS and real\u2010time PCR, with gut microbiota composition also assessed. We show that\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010oryzanol supplementation resulted in smaller, fewer lipid droplets in the liver compared with the HFD group, while GC\/MS analysis showed a decreasing trend in total and individual fatty acid content. Additionally, gut microbiota diversity improved in the Ory group. These findings align with previous rodent studies, suggesting that\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010oryzanol may suppress hepatic fat accumulation and inflammation. The study demonstrates the potential of\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010oryzanol as a functional food ingredient for preventing MASLD. Furthermore, this study supports the use of medaka as a cost\u2010effective and ethical alternative to rodent models in food science research.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70301","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:36:39Z","timestamp":1782891399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the effect of\n                    <scp>\u03b3<\/scp>\n                    \u2010oryzanol on\n                    <scp>MASLD<\/scp>\n                    pathology using a medaka fish model"],"prefix":"10.1002","author":[{"given":"Yukako","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University  Osaka 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Imaging Facility National Institute for Basic Biology  Okazaki Aichi Japan"},{"name":"Department of Basic Biology School of Life Science, The Graduate University for Advanced Studies (SOKENDAI)  Okazaki Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Tokumoto","sequence":"additional","affiliation":[{"name":"Department of Biology Graduate School of Science, Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University  Osaka Japan"},{"name":"Department of Nutrition Graduate School of Human Life and Ecology, Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-4652","authenticated-orcid":false,"given":"Shigeki","family":"Kamitani","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University  Osaka Japan"},{"name":"Department of Nutrition Graduate School of Human Life and Ecology, Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17050774","article-title":"The natural course of non\u2010alcoholic fatty liver disease","volume":"17","author":"Bertot LC","year":"2016","journal-title":"Int J Mol Sci"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an 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