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To establish a safer evaluation system, we constructed a noninfectious SARS\u2010CoV\u20102 replicon using a BAC vector driven by the CMV promoter. Among the tested cell lines, HuH\u20107.6c supported the most efficient replication. Replication was inhibited by remdesivir, nirmatrelvir, and molnupiravir, but not by favipiravir or AT\u2010527. A screening of 373 food\u2010derived compounds identified (20R)\u2010protopanaxadiol (PPD), a ginseng metabolite, as a novel inhibitor. Together, this work highlights this BAC\u2010vectored replicon as a practical platform for antiviral screening and identifies the potential of safe, food\u2010derived supplements in combating SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1002\/2211-5463.70307","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:48:19Z","timestamp":1784702899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of (\n                    <scp>20R<\/scp>\n                    )\u2010protopanaxadiol from\n                    <i>Panax ginseng<\/i>\n                    as a novel anti\u2010\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 compound"],"prefix":"10.1002","author":[{"given":"Midori","family":"Takeda","sequence":"first","affiliation":[{"name":"Division of Biological Information Technology, Joint 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