{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:41Z","timestamp":1792831061478,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"abstract":"<jats:p>\n                    Ultra\u2010potent synthetic opioids are powerful analgesics but also a leading cause of drug overdose deaths. Calcium\u2212\/voltage\u2010gated potassium channels of large conductance (BK) control vital physiological processes, with their accessory \u03b21 (encoded by\n                    <jats:italic>Kcnmb1<\/jats:italic>\n                    in mice) subunit being predominantly expressed in smooth muscle. Thus, we hypothesize that BK \u03b21 determines the effect of fentanyl on cerebral artery diameter. Here we report that fentanyl (0.001\u201310\u2009\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ) activates BK heteromers consisting of slo1\u2009+\u2009\u03b21 subunits in CHO cells, but not homomers of slo1. In\n                    <jats:italic>ex vivo<\/jats:italic>\n                    pressurized mouse cerebral arteries, pharmacological inhibition of BK or \u03b21 genetic deletion (\n                    <jats:italic>Kcnmb1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ) led to fentanyl\u2010induced vasoconstriction. Naloxone, an opioid receptor antagonist, ablates the fentanyl response in wild\u2010type cerebral arteries whereas mild constriction persists in\n                    <jats:italic>Kcnmb<\/jats:italic>\n                    <jats:italic>1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    arteries. Therefore, we identify BK \u03b21 as a functional fentanyl target which acts independently of opioid receptors to regulate fentanyl action on cerebral artery diameter.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70347","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:14:21Z","timestamp":1792829661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beta1 subunits enable fentanyl\u2010induced\n                    <scp>BK<\/scp>\n                    channel activation and opioid regulation of cerebral artery diameter"],"prefix":"10.1002","author":[{"given":"Shiwani","family":"Thapa","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Addiction Science and Toxicology, College of Medicine The University of Tennessee Health Science Center  Memphis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Nooh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science and Toxicology, College of Medicine The University of Tennessee Health Science Center  Memphis USA"},{"name":"Department of Biochemistry Faculty of Pharmacy Cairo University  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Geddati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science and Toxicology, College of Medicine The University of Tennessee Health Science Center  Memphis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-0096","authenticated-orcid":false,"given":"Alex","family":"Dopico","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science and Toxicology, College of Medicine The University of Tennessee Health Science Center  Memphis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-2319","authenticated-orcid":false,"given":"Anna N.","family":"Bukiya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science and Toxicology, College of Medicine The University of Tennessee Health Science Center  Memphis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Centers for Disease Control and PreventionUnited States dispensing rate maps. 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