{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:42:49Z","timestamp":1792582969008,"version":"4.5.0"},"reference-count":203,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013266","name":"MacDiarmid Institute for Advanced Materials and Nanotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"abstract":"<jats:p>\n                    Tissue engineering offers significant potential to advance the understanding and treatment of cardiac disease by generating\n                    <jats:italic>in vitro<\/jats:italic>\n                    models that recapitulate myocardial physiology in both healthy and diseased states. Specifically, hydrogel\u2010based systems have been widely employed to engineer 3D cardiac tissues due to their ability to support cell viability and mimic aspects of the extracellular matrix. However, conventional hydrogels are inherently isotropic and electrically insulating, limiting their capacity to reproduce the anisotropic structure and conductive properties of native myocardium. To address these limitations, increasingly sophisticated hydrogel platforms have been developed that incorporate conductive, piezoelectric and\/or aligned architectures to enhance electrical coupling, guide tissue organisation and promote cardiomyocyte maturation. These hydrogel\u2010based systems can also be tuned to recapitulate pathological states. Cardiac fibrosis is characterised by increased tissue stiffness, and researchers have sought to model this process by modulating the mechanical microenvironment to induce fibrotic phenotypes. With recently developed hydrogel platforms, mechanical properties can be controlled with both spatial and temporal precision, enabling systematic investigation of how dynamic and heterogeneous stiffness influences tissue formation, remodelling and disease progression. Although these platforms are not yet fully translational, they provide powerful tools to modulate multiple physiological parameters, thereby advancing our understanding of cardiac development and informing strategies to treat prevalent pathological conditions.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.70361","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:06:17Z","timestamp":1792580777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogel platforms for\n                    <scp>3D<\/scp>\n                    cardiac tissue engineering and fibrotic disease modelling"],"prefix":"10.1002","author":[{"given":"Harrison","family":"Porritt","sequence":"first","affiliation":[{"name":"Department of Chemical and Materials Engineering, Faculty of Engineering and Design The University of Auckland  New Zealand"},{"name":"The MacDiarmid Institute for Advanced 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Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.ard.2025.05.016","article-title":"Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis","volume":"84","author":"Ueberall L","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis \u2013 a short review of causes and therapeutic strategies","volume":"146","author":"Hinderer S","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1242\/jcs.029678","article-title":"Embryonic cardiomyocytes beat best on a matrix with heart\u2010like elasticity: scar\u2010like rigidity inhibits 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differentiated cardiac muscle construct","volume":"90","author":"Zimmermann W\u2010H","year":"2002","journal-title":"Circ Res"},{"key":"e_1_2_11_79_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26052309","article-title":"Hydrogels for cardiac tissue regeneration: current and future developments","volume":"26","author":"Holme S","year":"2025","journal-title":"Int J Mol Sci"},{"key":"e_1_2_11_80_1","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1021\/acsbiomaterials.9b00515","article-title":"Easy applied gelatin\u2010based hydrogel system for long\u2010term functional cardiomyocyte culture and myocardium formation","volume":"5","author":"Zhang F","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"e_1_2_11_81_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601434","article-title":"Engineered 3D cardiac fibrotic tissue to study fibrotic remodeling","volume":"6","author":"Sadeghi AH","year":"2017","journal-title":"Adv Healthc 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Macromol"},{"key":"e_1_2_11_91_1","doi-asserted-by":"crossref","first-page":"10603","DOI":"10.1021\/acsapm.4c01766","article-title":"Polyaniline\/poly(vinyl alcohol) conductive hydrogel for a chemiresistive ultrasensitive ammonia gas sensor","volume":"6","author":"Devi LS","year":"2024","journal-title":"ACS Appl Polym Mater"},{"key":"e_1_2_11_92_1","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1038\/s41467-018-05222-4","article-title":"Mechanically tunable conductive interpenetrating network hydrogels that mimic the elastic moduli of biological tissue","volume":"9","author":"Feig VR","year":"2018","journal-title":"Nat Commun"},{"key":"e_1_2_11_93_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201803951","article-title":"Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues","volume":"28","author":"Roshanbinfar K","year":"2018","journal-title":"Adv Funct Mater"},{"key":"e_1_2_11_94_1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/jbm.a.37729","article-title":"Electroconductive cardiac patch based on bioactive PEDOT: PSS hydrogels","volume":"112","author":"Sauvage E","year":"2024","journal-title":"J Biomed Mater Res A"},{"key":"e_1_2_11_95_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.carbon.2021.08.059","article-title":"Carbon nanotubes for cardiac tissue regeneration: state of the art and perspectives","volume":"184","author":"Barrej\u00f3n M","year":"2021","journal-title":"Carbon"},{"key":"e_1_2_11_96_1","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering8060080","article-title":"Carbon nanotube\u2010based scaffolds for cardiac tissue engineering\u2014systematic review and narrative synthesis","volume":"8","author":"Scott L","year":"2021","journal-title":"Bioengineering (Basel)"},{"key":"e_1_2_11_97_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/nn203711s","article-title":"Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation","volume":"6","author":"Shin SR","year":"2012","journal-title":"ACS Nano"},{"key":"e_1_2_11_98_1","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1021\/nn305559j","article-title":"Carbon\u2010nanotube\u2010embedded hydrogel sheets for engineering cardiac constructs and bioactuators","volume":"7","author":"Shin SR","year":"2013","journal-title":"ACS Nano"},{"key":"e_1_2_11_99_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymertesting.2022.107905","article-title":"3D printing of graphene oxide\/carbon nanotubes hydrogel circuits for multifunctional fire alarm and protection","volume":"119","author":"Chen X","year":"2023","journal-title":"Polymer Test"},{"key":"e_1_2_11_100_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.actbio.2016.10.025","article-title":"Carbon nanotube\u2010composite hydrogels promote intercalated disc assembly in engineered cardiac tissues through \u03b21\u2010integrin mediated FAK and RhoA pathway","volume":"48","author":"Sun H","year":"2017","journal-title":"Acta Biomater"},{"key":"e_1_2_11_101_1","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1002\/adma.201301082","article-title":"Cell\u2010laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide","volume":"25","author":"Shin SR","year":"2013","journal-title":"Adv Mater"},{"key":"e_1_2_11_102_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111844","article-title":"Electrical stimulation of neonatal rat cardiomyocytes using conductive polydopamine\u2010reduced graphene oxide\u2010hybrid hydrogels for constructing cardiac microtissues","volume":"205","author":"Li X\u2010P","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"e_1_2_11_103_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/1673-5374.343889","article-title":"Reduced graphene oxide\u2010embedded nerve conduits loaded with bone marrow mesenchymal stem cell\u2010derived extracellular vesicles promote peripheral nerve regeneration","volume":"18","author":"Zhang W","year":"2023","journal-title":"Neural Regen Res"},{"key":"e_1_2_11_104_1","doi-asserted-by":"crossref","first-page":"47704","DOI":"10.1039\/C7RA08960K","article-title":"Multi\u2010functional thermo\u2010crosslinkable collagen\u2010metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold","volume":"7","author":"Hosoyama K","year":"2017","journal-title":"RSC Adv"},{"key":"e_1_2_11_105_1","first-page":"339","article-title":"An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair","volume":"20","author":"Zhang L","year":"2023","journal-title":"Bioact Mater"},{"key":"e_1_2_11_106_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/jbcr\/iraa205","article-title":"Incorporation of silver nanoparticles in hydrogel matrices for controlling wound infection","volume":"42","author":"Pangli H","year":"2021","journal-title":"J Burn Care Res"},{"key":"e_1_2_11_107_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actbio.2016.05.027","article-title":"Gold nanorod\u2010incorporated gelatin\u2010based conductive hydrogels for engineering cardiac tissue constructs","volume":"41","author":"Navaei A","year":"2016","journal-title":"Acta Biomater"},{"key":"e_1_2_11_108_1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/acsami.9b17907","article-title":"Coadministration of an adhesive conductive hydrogel patch and an injectable hydrogel to treat myocardial infarction","volume":"12","author":"Wu T","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"e_1_2_11_109_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/polym3010527","article-title":"A 3D electroactive polypyrrole\u2010collagen fibrous scaffold for tissue engineering","volume":"3","author":"Yow S\u2010Z","year":"2011","journal-title":"Polymers"},{"key":"e_1_2_11_110_1","doi-asserted-by":"crossref","first-page":"22152","DOI":"10.1021\/acsami.9b05520","article-title":"Cell\u2010laden Electroconductive hydrogel simulating nerve matrix to deliver electrical cues and promote neurogenesis","volume":"11","author":"Wu C","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"e_1_2_11_111_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/cns.13135","article-title":"Polypyrrole\/polylactic acid nanofibrous scaffold cotransplanted with bone marrow stromal cells promotes the functional recovery of spinal cord injury in rats","volume":"25","author":"Raynald","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"e_1_2_11_112_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2018.10.031","article-title":"Restoring electrical connection using a conductive biomaterial provides a new therapeutic strategy for rats with spinal cord injury","volume":"692","author":"Shu B","year":"2019","journal-title":"Neurosci Lett"},{"key":"e_1_2_11_113_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/mabi.201600148","article-title":"Polypyrrole\/alginate hybrid hydrogels: electrically conductive and soft biomaterials for human mesenchymal stem cell culture and potential neural tissue engineering applications","volume":"16","author":"Yang S","year":"2016","journal-title":"Macromol Biosci"},{"key":"e_1_2_11_114_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202403642","article-title":"Electrically conductive collagen\u2010PEDOT:PSS hydrogel prevents post\u2010infarct cardiac arrhythmia and supports hiPSC\u2010cardiomyocyte function","volume":"36","author":"Roshanbinfar K","year":"2024","journal-title":"Adv Mater"},{"key":"e_1_2_11_115_1","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.2147\/IJN.S128030","article-title":"Carbon nanotube\u2010incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs","volume":"12","author":"Sun H","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"e_1_2_11_116_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nnano.2011.160","article-title":"Nanowired three\u2010dimensional cardiac patches","volume":"6","author":"Dvir T","year":"2011","journal-title":"Nat Nanotechnol"},{"key":"e_1_2_11_117_1","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1039\/D3NR05422E","article-title":"Improving the development of human engineered cardiac tissue by gold nanorods embedded extracellular matrix for long\u2010term 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Mater"},{"key":"e_1_2_11_121_1","doi-asserted-by":"crossref","DOI":"10.3390\/mi14010167","article-title":"Recent progress on hydrogel\u2010based piezoelectric devices for biomedical applications","volume":"14","author":"Du Y","year":"2023","journal-title":"Micromachines (Basel)"},{"key":"e_1_2_11_122_1","doi-asserted-by":"crossref","first-page":"45853","DOI":"10.1021\/acsami.2c13074","article-title":"Enhancing strain\u2010sensing properties of the conductive hydrogel by introducing PVDF\u2010TrFE","volume":"14","author":"Hu Z","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"e_1_2_11_123_1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/bit.25918","article-title":"The effect of PVDF\u2010TrFE scaffolds on stem cell derived cardiovascular cells","volume":"113","author":"Hitscherich P","year":"2016","journal-title":"Biotechnol Bioeng"},{"key":"e_1_2_11_124_1","doi-asserted-by":"crossref","DOI":"10.1002\/admt.201900820","article-title":"Electrospun fibrous PVDF\u2010TrFe scaffolds for cardiac tissue engineering, differentiation, and maturation","volume":"5","author":"Adadi N","year":"2020","journal-title":"Adv Mater Technol"},{"key":"e_1_2_11_125_1","doi-asserted-by":"crossref","first-page":"21778","DOI":"10.1021\/acsanm.4c03749","article-title":"PVDF\u2010modified graphene nanosheets as a piezoelectric and electroconductive bilayer platform for cardiac cell stimulation","volume":"7","author":"Golafshan E","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"e_1_2_11_126_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202401561","article-title":"Multimaterial printing of serpentine microarchitectures with synergistic mechanical\/piezoelectric stimulation for enhanced cardiac\u2010specific functional regeneration","volume":"20","author":"Han K","year":"2024","journal-title":"Small"},{"key":"e_1_2_11_127_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10544-010-9490-6","article-title":"Preparation, characterization and in vitro testing of poly(lactic\u2010co\u2010glycolic) acid\/barium titanate nanoparticle composites for enhanced cellular proliferation","volume":"13","author":"Ciofani G","year":"2011","journal-title":"Biomed Microdevices"},{"key":"e_1_2_11_128_1","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1021\/acsabm.1c00567","article-title":"Electroactive smart materials for neural tissue regeneration","volume":"4","author":"Pinho TS","year":"2021","journal-title":"ACS Appl Bio Mater"},{"key":"e_1_2_11_129_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcs7050200","article-title":"Fabrication and characterization of piezoelectric PEO\/SF\/BaTiO3 scaffolds for cardiac tissue engineering","volume":"7","author":"Khalil AKA","year":"2023","journal-title":"J Compos Sci"},{"key":"e_1_2_11_130_1","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1016\/j.biomaterials.2005.01.052","article-title":"Electrospun fine\u2010textured scaffolds for heart tissue constructs","volume":"26","author":"Zong X","year":"2005","journal-title":"Biomaterials"},{"key":"e_1_2_11_131_1","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1016\/j.biomaterials.2011.04.042","article-title":"Electrospun nanofibers as a tool for architecture control in engineered cardiac tissue","volume":"32","author":"Orlova Y","year":"2011","journal-title":"Biomaterials"},{"key":"e_1_2_11_132_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jbm.b.31862","article-title":"Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering","volume":"98","author":"Kai D","year":"2011","journal-title":"J Biomed Mater Res"},{"key":"e_1_2_11_133_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02980-w","article-title":"GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects","volume":"22","author":"Yu C","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"e_1_2_11_134_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122484","article-title":"The recent advancement in the PLGA\u2010based thermo\u2010sensitive hydrogel for smart drug delivery","volume":"631","author":"Rahmani F","year":"2023","journal-title":"Int J Pharm"},{"key":"e_1_2_11_135_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41563-023-01611-3","article-title":"Fibre\u2010infused gel scaffolds guide cardiomyocyte alignment in 3D\u2010printed ventricles","volume":"22","author":"Choi S","year":"2023","journal-title":"Nat Mater"},{"key":"e_1_2_11_136_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202524101","article-title":"Controlling 3D contractility via engineered fibrous hydrogel composites","volume":"36","author":"Xu KL","year":"2026","journal-title":"Adv Funct Mater"},{"key":"e_1_2_11_137_1","first-page":"551","article-title":"Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high\u2010fidelity drug screening","volume":"45","author":"Wang Y","year":"2025","journal-title":"Bioact Mater"},{"key":"e_1_2_11_138_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202500261","article-title":"Filamented light (FLight) biofabrication of aligned fibrillar structures to direct 3D cell organization within microgels","volume":"21","author":"Joshi A","year":"2025","journal-title":"Small"},{"key":"e_1_2_11_139_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302179","article-title":"FLight biofabrication supports maturation of articular cartilage with anisotropic properties","volume":"13","author":"Puiggal\u00ed\u2010Jou A","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"e_1_2_11_140_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404509","article-title":"Multidirectional filamented light biofabrication creates aligned and contractile cardiac tissues","volume":"11","author":"Jones LS","year":"2024","journal-title":"Adv Sci"},{"key":"e_1_2_11_141_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202508899","article-title":"Two\u2010photon polymerized 3D geometries to study single\u2010cell mechanotransduction and force generation in mesenchymal stromal cells","volume":"22","author":"Perera WR","year":"2026","journal-title":"Small"},{"key":"e_1_2_11_142_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.optcom.2024.131161","article-title":"Two\u2010photon polymerization of hydrogel cellular scaffolds","volume":"574","author":"He Z","year":"2025","journal-title":"Opt Commun"},{"key":"e_1_2_11_143_1","doi-asserted-by":"crossref","first-page":"21549","DOI":"10.1038\/s41598-025-06269-2","article-title":"Two\u2010photon polymerization based 4D printing of poly(N\u2010isopropylacrylamide) hydrogel microarchitectures for reversible shape morphing","volume":"15","author":"Yarali E","year":"2025","journal-title":"Sci Rep"},{"key":"e_1_2_11_144_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301388","article-title":"Granular hydrogels in biofabrication: recent advances and future perspectives","volume":"13","author":"Daly AC","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"e_1_2_11_145_1","doi-asserted-by":"crossref","first-page":"034105","DOI":"10.1088\/1758-5090\/ac6b58","article-title":"Cartilage tissue engineering by extrusion bioprinting utilizing porous hyaluronic acid microgel bioinks","volume":"14","author":"Fl\u00e9geau K","year":"2022","journal-title":"Biofabrication"},{"key":"e_1_2_11_146_1","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1039\/D3MA00715D","article-title":"An insight into synthesis, properties and applications of gelatin methacryloyl hydrogel for 3D bioprinting","volume":"4","author":"Ghosh RN","year":"2023","journal-title":"Mater 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Physiol"},{"key":"e_1_2_11_193_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cm.20331","article-title":"Guiding cell migration in 3D: a collagen matrix with graded directional stiffness","volume":"66","author":"Hadjipanayi E","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"key":"e_1_2_11_194_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-bioeng-020625-023632","article-title":"Viscoelasticity of the heart: an overview of viscoelastic measurements at different scales","volume":"28","author":"Gionet\u2010Gonzales M","year":"2026","journal-title":"Annu Rev Biomed Eng"},{"key":"e_1_2_11_195_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10237-024-01909-4","article-title":"Stress relaxation rates of myocardium from failing and non\u2010failing hearts","volume":"24","author":"Gionet\u2010Gonzales M","year":"2025","journal-title":"Biomech Model Mechanobiol"},{"key":"e_1_2_11_196_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106571","article-title":"Investigations of cardiac fibrosis rheology by in vitro cardiac tissue modeling with 3D cellular spheroids","volume":"155","author":"Zanetti M","year":"2024","journal-title":"J Mech Behav Biomed Mater"},{"key":"e_1_2_11_197_1","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1021\/acsbiomaterials.1c01006","article-title":"milliPillar: a platform for the generation and real\u2010time assessment of human engineered cardiac tissues","volume":"7","author":"Tamargo MA","year":"2021","journal-title":"ACS Biomater Sci Eng"},{"key":"e_1_2_11_198_1","doi-asserted-by":"crossref","unstructured":"Dostani\u0107M WindtLM WiendelsM Van MeerBJ MummeryCL SarroPMandMastrangeliM(2023)highly reproducible tissue positioning with tapered pillar design in engineered heart tissue platforms. In 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS) pp. 374\u2013377. IEEE Munich Germany.","DOI":"10.1109\/MEMS49605.2023.10052166"},{"key":"e_1_2_11_199_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2023.100626","article-title":"Continuous contractile force and electrical signal recordings of 3D cardiac tissue utilizing conductive hydrogel pillars on a chip","volume":"20","author":"Zhang F","year":"2023","journal-title":"Mater Today Bio"},{"key":"e_1_2_11_200_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celbio.2026.100405","article-title":"Digital light processing 3D printing enables versatile fabrication of human engineered heart tissues","volume":"2","author":"Dhand AP","year":"2026","journal-title":"Cell Biomater"},{"key":"e_1_2_11_201_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.yjmcc.2018.03.016","article-title":"Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues","volume":"118","author":"Leonard A","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"e_1_2_11_202_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.actbio.2026.01.018","article-title":"3D digital light processing bioprinting and in situ differentiation of hiPSCs for engineering cardiac tissue","volume":"212","author":"Banerjee A","year":"2026","journal-title":"Acta Biomater"},{"key":"e_1_2_11_203_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202409355","article-title":"Multi\u2010material volumetric bioprinting and plug\u2010and\u2010play suspension Bath biofabrication via bioresin molecular weight tuning and via multiwavelength alignment optics","volume":"37","author":"Ribezzi D","year":"2025","journal-title":"Adv Mater"},{"key":"e_1_2_11_204_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1425073","article-title":"Advances in melt electrowriting for cardiovascular applications","volume":"12","author":"Mueller KMA","year":"2024","journal-title":"Front Bioeng Biotechnol"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.70361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.70361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.70361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:06:44Z","timestamp":1792580804000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.70361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":203,"alternative-id":["10.1002\/2211-5463.70361"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.70361","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2211-5463.70361"}}