{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:30:35Z","timestamp":1794349835927,"version":"4.9.0"},"edition-number":"1","reference-count":36,"publisher":"Wiley","isbn-type":[{"value":"9780471910978","type":"print"},{"value":"9780470513521","type":"electronic"}],"license":[{"start":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:00:00Z","timestamp":1190937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/9780470513521.ch8","type":"other","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T08:47:53Z","timestamp":1190969273000},"page":"109-123","source":"Crossref","is-referenced-by-count":6,"title":["Structure \u2013 Functton Relationship of Tumour Necrosis Factor and its Mechanism of Action"],"prefix":"10.1002","author":[{"given":"W.","family":"Fiers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Brouckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kettelhut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Suffys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tavernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vanhaesebroeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Van Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,28]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3990","article-title":"Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons","volume":"46","author":"Balkwill FR","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/320584a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380521"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7467"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.2.446"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","unstructured":"DefilippiP PoupartP HaegemanG TavernierJ FiersW ContentJ1987Induction of 26 kDa protein mRNA in human cells treated with recombinant human tumor necrosis factor (rTNF).Proc Natl Acad Sci USA in press","DOI":"10.1073\/pnas.84.13.4557"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.6.1433"},{"key":"e_1_2_1_9_1","first-page":"241","volume-title":"The biology of the interferon system","author":"Fiers W","year":"1986"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1986.051.01.071"},{"key":"e_1_2_1_11_1","unstructured":"FiersW BrouckaertP DevosRet al1987Molecular and cellular biology of Tumor Necrosis Factor Interferon gamma and their synergism. In: Cantell K Schellekens H (eds) Proceedings of the 1986 ISIR\u2010TNO Meeting on the Interferon System. Kluwer Academic Publishers Group Dordrecht in press"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(84)90111-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.12.4417"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90025-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90107-0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/312721a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1986.tb09931.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.11.3814"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","unstructured":"KettelhutI FiersW GoldbergAL1987The toxic effects of Tumor Necrosis Factorin vivoand their prevention by cyclooxygenase inhibitors.Proc Natl Acad Sci USA in press","DOI":"10.1073\/pnas.84.12.4273"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90780-4"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1985.tb09226.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","unstructured":"PoberJS1987Effects of tumour necrosis factor and related cytokines on vascular endothelial cells. This volume p170\u2013184","DOI":"10.1002\/9780470513521.ch12"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.5.1680"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3839597"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3764421"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112418"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","unstructured":"KettelhutIC FiersW GoldbergAJ1987The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.Proc Natl Acad Sci USA in press","DOI":"10.1073\/pnas.84.12.4273"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90780-4"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/288095a0"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90151-6"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.914"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(83)90337-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/299833a0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7152"},{"key":"e_1_2_1_36_1","first-page":"73","volume-title":"The interferon system","author":"Zilberstein A","year":"1985"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/j.1460-2075.1986.tb04531.x","article-title":"Structure and expression of cDNA and genes for human interferon\u2010\u03b2\u20102, a distinct species induced by growth\u2010stimulatory cytokines","volume":"5","author":"Zilberstein A","year":"1986","journal-title":"EMBO (Eur Mol Biol Organ) J"}],"container-title":["Novartis Foundation Symposia","Ciba Foundation Symposium 131 \u2010 Tumour Necrosis Factor and Related Cytotoxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/9780470513521.ch8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T09:38:30Z","timestamp":1693129110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/9780470513521.ch8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,28]]},"ISBN":["9780471910978","9780470513521"],"references-count":36,"alternative-id":["10.1002\/9780470513521.ch8","10.1002\/SERIES1767","10.1002\/9780470513521"],"URL":"https:\/\/doi.org\/10.1002\/9780470513521.ch8","archive":["Portico"],"relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1002\/9780470513521","asserted-by":"object"}]},"ISSN":["1935-4657"],"issn-type":[{"value":"1935-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,28]]}}}