{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:03:15Z","timestamp":1770469395679,"version":"3.49.0"},"edition-number":"1","reference-count":63,"publisher":"Wiley","isbn-type":[{"value":"9780470663424","type":"print"},{"value":"9780470720325","type":"electronic"}],"license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,1]]},"DOI":"10.1002\/9780470720325.ch7","type":"other","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T07:57:24Z","timestamp":1212134244000},"page":"125-144","source":"Crossref","is-referenced-by-count":4,"title":["Transferrin: Physiology and Function in Iron Transport"],"prefix":"10.1002","author":[{"given":"Elmer B.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"213","article-title":"The physics and physiology of transferrin","volume":"3","author":"Aisen P.","year":"1970","journal-title":"Mt. Sinai J. Med."},{"key":"e_1_2_1_3_1","first-page":"280","volume-title":"Inorganic Biochemistry","author":"Aisen P.","year":"1974"},{"key":"e_1_2_1_4_1","first-page":"25","volume-title":"Progress in Hematology","author":"Aisen P.","year":"1975"},{"key":"e_1_2_1_5_1","first-page":"31","article-title":"The iron binding function of transferrin in iron metabolism","volume":"14","author":"Aisen P.","year":"1977","journal-title":"Semin. Hematol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90759-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90372-0"},{"key":"e_1_2_1_8_1","first-page":"769","article-title":"In vivo evidence for the functional heterogeneity of transferrin\u2010bound iron. I. Studies in normal rats","volume":"85","author":"Awai M.","year":"1975","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_9_1","first-page":"785","article-title":"In vivo evidence for the functional heterogeneity of transferrin\u2010bound iron. II. Studies in pregnant rats","volume":"85","author":"Awai M.","year":"1975","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00831a046"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00835a040"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80213-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/S0021-9258(19)44032-5","article-title":"The reaction of ferric salts with transferrin","volume":"248","author":"Bates G. W.","year":"1973","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00883.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1152\/ajplegacy.1958.193.3.615","article-title":"Iron metabolism in the pregnant rabbit. Iron transport across the placenta","volume":"193","author":"Bothwell T. H.","year":"1958","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_16_1","first-page":"576","article-title":"In vivo evidence for the functional heterogeneity of transferrin\u2010bound iron. III. Studies of transferrin at high and low iron saturation","volume":"86","author":"Brown E. B.","year":"1975","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_17_1","first-page":"613","volume-title":"Iron in Biochemistry and Medicine","author":"Cavill I.","year":"1974"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/226356a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1152\/ajplegacy.1959.197.1.87","article-title":"Transfer of radioactive iron via the placenta and accessory fetal membranes in the rabbit","volume":"197","author":"Davies J.","year":"1959","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_20_1","first-page":"280","article-title":"Studies with doubly labeled iron. IV. Evidence for a second iron binding system in plasma","volume":"61","author":"Dern R. J.","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90077-7"},{"key":"e_1_2_1_22_1","first-page":"273","article-title":"Variation in the availability of transferrin\u2010bound iron for uptake by immature cells","volume":"37","author":"Fletcher J.","year":"1969","journal-title":"Clin. Sci. (Oxf.)"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/215584a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/2181211a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(73)90735-3"},{"key":"e_1_2_1_26_1","first-page":"129","volume-title":"Genetic Markers in Human Blood","author":"Giblett E. R.","year":"1969"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/ajplegacy.1968.215.1.205","article-title":"Transfer of iron across the placenta and fetal membranes in the rat","volume":"215","author":"Glasser S. R.","year":"1968","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1182\/blood.V40.2.239.239","article-title":"A family of congenital atransferrin\u2010emia","volume":"40","author":"Goya N.","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000208194"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00673a011"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/257821a0"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1113001"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06639.x"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.01-0944"},{"key":"e_1_2_1_34_1","first-page":"905","article-title":"Ferrokinetics: a study of transport iron in plasma","volume":"64","author":"Hosain F.","year":"1964","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_35_1","unstructured":"Huebers H.&Huebers E.(1976)Isolation and identification of isotransferrins from rat plasma in16th International Congress of Hematology p.113\u2013114(abstr.)."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104718"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103786"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091860203"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(69)90175-5"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01658.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0380783"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00937.x"},{"key":"e_1_2_1_43_1","first-page":"29","volume-title":"Iron in Biochemistry and Medicine","author":"Morgan E. H.","year":"1974"},{"key":"e_1_2_1_44_1","unstructured":"Okada S. Rossmann M. D.&Brown E. B.(1976)Functional heterogeneity of transferrin: studies of pH\u2010mediated radioiron release and citrate\u2010mediated exchange in16th International Congress of Hematology p.114(abstr.)."},{"key":"e_1_2_1_45_1","first-page":"51","article-title":"In vivo evidence for the functional heterogeneity of transferrin\u2010bound iron. IV. Selective uptake by erythroid precursors of radio\u2010iron from portal vein plasma transferrin during intestinal iron absorption","volume":"89","author":"Okada S.","year":"1977","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","unstructured":"Po\u0148ka P. Neuwirt J. Borov\u00e1 J.&Fuchs O.(1977)Control of iron delivery to the haemoglobin molecule in erythroid cells inThis Volume pp.167\u2013188.","DOI":"10.1002\/9780470720325.ch9"},{"key":"e_1_2_1_47_1","unstructured":"Pootrukul P.&Finch C. A.(1976)The role of transferrin in determining internal iron distribution in16th International Congress of Hematology p.115(abstr.)."},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/255087a0"},{"key":"e_1_2_1_49_1","first-page":"166","article-title":"Functional heterogeneity and pH\u2010dependent dissociation properties of human transferrin","volume":"428","author":"Princiotto J. V.","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41699-2"},{"key":"e_1_2_1_51_1","first-page":"141","volume-title":"Proteins of Iron Storage and Transport in Biochemistry and Medicine","author":"Sly D. A.","year":"1975"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90373-3"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1182\/blood.V47.1.133.133","article-title":"Micropinocytosis of transferrin by developing red cells: an electron microscopic study utilizing ferritin\u2010conjugated transferrin and ferritin\u2010conjugated antibodies to transferrin","volume":"47","author":"Sullivan A. L.","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104892"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1973.sp002190"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(75)90256-1"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90482-2"},{"key":"e_1_2_1_58_1","first-page":"613","volume-title":"Iron in Biochemistry and Medicine","author":"Cavill I.","year":"1974"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(75)90488-X"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/257821a0"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00937.x"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198114"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/255087a0"}],"container-title":["Novartis Foundation Symposia","Ciba Foundation Symposium 51 \u2010 Iron Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F9780470720325.ch7","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/9780470720325.ch7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:42:20Z","timestamp":1692985340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/9780470720325.ch7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"ISBN":["9780470663424","9780470720325"],"references-count":63,"alternative-id":["10.1002\/9780470720325.ch7","10.1002\/SERIES1767","10.1002\/9780470720325"],"URL":"https:\/\/doi.org\/10.1002\/9780470720325.ch7","archive":["Portico"],"relation":{},"ISSN":["1935-4657"],"issn-type":[{"value":"1935-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}