{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:10:05Z","timestamp":1789938605971,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Microbiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:italic>Vibrio cholerae<\/jats:italic> is the agent of cholera, a potentially lethal diarrheal disease that remains a significant threat to populations in developing nations. The infant rabbit model of cholera is the only non\u2010surgical small animal model system that closely mimics human cholera. Following orogastric inoculation, <jats:italic>V. cholerae<\/jats:italic> colonizes the intestines of infant rabbits, and the animals develop severe cholera\u2010like diarrhea. In this unit, we provide a detailed description of the preparation of the <jats:italic>V. cholerae<\/jats:italic> inoculum, the inoculation process and the collection and processing of tissue samples. This infection model is useful for studies of <jats:italic>V. cholerae<\/jats:italic> factors and mechanisms that promote its intestinal colonization and enterotoxicity, as well as the host response to infection. The infant rabbit model of cholera enables investigations that will further our understanding of the pathophysiology of cholera and provides a platform for testing new therapeutics. \u00a9 2015 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/9780471729259.mc06a06s38","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T13:55:39Z","timestamp":1438610139000},"source":"Crossref","is-referenced-by-count":17,"title":["Infant Rabbit Model for Diarrheal Diseases"],"prefix":"10.1002","volume":"38","author":[{"given":"S\u00f6ren","family":"Abel","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School  Boston Massachusetts"},{"name":"Division of Infectious Diseases, Brigham and Women's Hospital  Boston Massachusetts"},{"name":"Department of Pharmacy, Faculty of Health Sciences, UiT, The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K.","family":"Waldor","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School  Boston Massachusetts"},{"name":"Division of Infectious Diseases, Brigham and Women's Hospital  Boston Massachusetts"},{"name":"Howard Hughes Medical Institute  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3253"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.4.376"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0010008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc01a01s13"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt654"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/1831533a0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700660228"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1955.tb00074.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.2.472-478.1992"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.104.3.411"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.11.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.10.1.167-172.1974"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003800"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.48"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.56.11.2871-2875.1988"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.33.2.616-619.1981"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.007"},{"key":"e_1_2_9_19_1","first-page":"557","article-title":"Recherches sur le cholera et les vibrions. 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