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The ability to rapidly adapt to environmental changes is therefore presumed to be central to spirochete survival and pathogenic programs. Indeed, it has now been well established that tick feeding initiates extensive changes in both gene expression and protein composition, collectively referred to as \u201chost adaptation,\u201d a process that is thought to continue throughout infection. The paucibacillary nature of borrelial infections, however, has hampered our ability to study this bacterium in vivo. To circumvent this limitation, an animal model was developed for obtaining sufficient numbers of organisms to directly examine differential gene expression and antigenic composition of <jats:named-content content-type=\"genus-species\"><jats:italic>B. burgdorferi<\/jats:italic><\/jats:named-content> within the context of the mammalian host. The DMC model allows for a direct comparison of host\u2010adapted <jats:named-content content-type=\"genus-species\"><jats:italic>B. burgdorferi<\/jats:italic><\/jats:named-content> and their in vitro\u2010cultivated counterparts.<\/jats:p>","DOI":"10.1002\/9780471729259.mc12c03s00","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T15:16:32Z","timestamp":1138720592000},"source":"Crossref","is-referenced-by-count":11,"title":["Cultivation of <i>Borrelia burgdorferi<\/i> in Dialysis Membrane Chambers in Rat Peritonea"],"prefix":"10.1002","volume":"00","author":[{"given":"Melissa J.","family":"Caimano","sequence":"first","affiliation":[{"name":"University of Connecticut Health Center  Farmington Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7]]},"reference":[{"key":"e_1_2_6_2_1_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2325"},{"key":"e_1_2_6_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00036-6"},{"key":"e_1_2_6_2_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3371-3383.2003"},{"key":"e_1_2_6_2_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6433-6445.2004"},{"key":"e_1_2_6_2_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/514200"},{"key":"e_1_2_6_2_6_1","first-page":"1.6.1","volume-title":"Current Protocols in Immunology","author":"Donovan J.","year":"1995"},{"key":"e_1_2_6_2_7_1","first-page":"1.8.1","volume-title":"Current Protocols in Immunology","author":"Donovan J.","year":"1995"},{"key":"e_1_2_6_2_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.2139-2150.2002"},{"key":"e_1_2_6_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012263951-7\/50028-4"},{"key":"e_1_2_6_2_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3618-3627.2001"},{"key":"e_1_2_6_2_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.5042-5055.2003"},{"key":"e_1_2_6_2_12_1","first-page":"111","article-title":"Studies on early events of Borrelia burgdorferi\u2013induced cytokine production in immunodeficient SCID mice by using a tissue chamber model for acute inflammation","volume":"76","author":"Hurtenbach U.","year":"1995","journal-title":"Int. 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