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Reservoir hosts are typically asymptomatic. In contrast to the hamster model of leptospirosis (described in <jats:sc><jats:italic>UNIT 12E.2<\/jats:italic><\/jats:sc>), which emulates the severe form of human leptospirosis, the rat model of chronic leptospirosis emulates the asymptomatic infection observed in reservoir hosts. Rats are the primary reservoir host for pathogenic <jats:italic>Leptospira<\/jats:italic> species associated with the severe forms of human leptospirosis.<\/jats:p>","DOI":"10.1002\/9780471729259.mc12e03s20","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T15:13:36Z","timestamp":1296832416000},"source":"Crossref","is-referenced-by-count":24,"title":["Rat Model of Chronic Leptospirosis"],"prefix":"10.1002","volume":"20","author":[{"given":"Rub\u00e9n","family":"Bonilla\u2010Santiago","sequence":"first","affiliation":[{"name":"Veterinary Sciences Centre UCD School of Agriculture Food Science &amp; Veterinary Medicine UCD Conway Institute of Biomolecular and Biomedical Research College of Life Sciences University College Dublin Belfield Dublin Republic of Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarlath E.","family":"Nally","sequence":"additional","affiliation":[{"name":"Veterinary Sciences Centre UCD School of Agriculture Food Science &amp; Veterinary Medicine UCD Conway Institute of Biomolecular and Biomedical Research College of Life Sciences University College Dublin Belfield Dublin Republic of Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2007.10.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00830-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.995"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0103s73"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0106s73"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000612"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.26.3.341"},{"key":"e_1_2_9_9_1","first-page":"736","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"Ko A.I.","year":"2009","journal-title":"Nature Rev."},{"key":"e_1_2_9_10_1","volume-title":"Spirochetes in Body Fluids and Tissues","author":"Miller J.N.","year":"1971"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00511-08"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.08-VP-0265-N-REV"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3251-3260.2005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0991-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1977.26.970"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-17.1.39"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470751077"}],"container-title":["Current Protocols in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/9780471729259.mc12e03s20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/9780471729259.mc12e03s20","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/9780471729259.mc12e03s20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:19:26Z","timestamp":1693617566000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/9780471729259.mc12e03s20"}},"subtitle":["Spirochetes"],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/9780471729259.mc12e03s20"],"URL":"https:\/\/doi.org\/10.1002\/9780471729259.mc12e03s20","archive":["Portico"],"relation":{},"ISSN":["1934-8525","1934-8533"],"issn-type":[{"value":"1934-8525","type":"print"},{"value":"1934-8533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}