{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:00:01Z","timestamp":1776103201505,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM008339"],"award-info":[{"award-number":["T32 GM008339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001774","name":"New Jersey Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Intelligent Systems"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Controlled\/living radical polymerization (CLRP) techniques are widely utilized to synthesize advanced and controlled synthetic polymers for chemical and biological applications. While automation has long stood as a high\u2010throughput (HTP) research tool to increase productivity as well as synthetic\/analytical reliability and precision, oxygen intolerance of CLRP has limited the widespread adoption of these systems. Recently, however, oxygen\u2010tolerant CLRP techniques, such as oxygen\u2010tolerant photoinduced electron\/energy transfer\u2013reversible addition\u2013fragmentation chain transfer (PET\u2013RAFT), enzyme degassing of RAFT (Enz\u2010RAFT), and atom\u2010transfer radical polymerization (ATRP), have emerged. Herein, the use of a Hamilton MLSTARlet liquid handling robot for automating CLRP reactions is demonstrated. Synthesis processes are developed using Python and used to automate reagent handling, dispensing sequences, and synthesis steps required to create homopolymers, random heteropolymers, and block copolymers in 96\u2010well plates, as well as postpolymerization modifications. Using this approach, the synergy between highly customizable liquid handling robotics and oxygen\u2010tolerant CLRP to automate advanced polymer synthesis for HTP and combinatorial polymer research is demonstrated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.201900126","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T09:14:44Z","timestamp":1575364484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Automation of Controlled\/Living Radical Polymerization"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-172X","authenticated-orcid":false,"given":"Matthew","family":"Tamasi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Rutgers, The State University of New Jersey  Piscataway NJ 08854 USA"}]},{"given":"Shashank","family":"Kosuri","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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