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Herein, the latest advancements in structural engineering strategies are summarized for the improvement of sensing performances of flexible and stretchable strain sensors. Porous structures, wrinkled structures, and overlapped structures can increase the sensing range significantly. High sensitivity of strain sensors can be achieved by crack structures in thin film and strain concentration structures in substrate. Strain sensors with hierarchical structures are able to have both high sensitivity and wide sensing range. Moreover, potential applications of flexible and stretchable strain sensors fabricated with engineered structures are presented. The study is concluded with analysis of challenges and future perspectives for structural engineering strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202000194","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T03:28:43Z","timestamp":1606447723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Structural Engineering for High\u2010Performance Flexible and Stretchable Strain Sensors"],"prefix":"10.1002","volume":"3","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Flexible Electronics Research Center State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology  Wuhan Hubei 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouping","family":"Yin","sequence":"additional","affiliation":[{"name":"Flexible Electronics Research Center State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology  Wuhan Hubei 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-0848","authenticated-orcid":false,"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Flexible Electronics Research Center State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology  Wuhan Hubei 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201304248"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15894"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21836"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2019.05.046"},{"key":"e_1_2_9_6_1","first-page":"9","volume":"30","author":"Yao G.","year":"2020","journal-title":"Adv. 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