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Among them, several generations of tissue\u2010engineered biohybrid walkers have been established as reliable platforms to study untethered locomotion. However, despite these advances, such technology is not mature yet, and major challenges remain. Herein, steps are taken to address two of them: the lack of systematic design approaches, common to biohybrid robotics in general, and in the case of biohybrid walkers specifically, the lack of maneuverability. A dual\u2010ring biobot is presented which is computationally designed and selected to exhibit robust forward motion and rotational steering. This dual\u2010ring biobot consists of two independent muscle actuators and a four\u2010legged scaffold asymmetric in the fore\/aft direction. The integration of multiple muscles within its body architecture, combined with differential electrical stimulation, allows the robot to maneuver. The dual\u2010ring robot design is then fabricated and experimentally tested, confirming computational predictions and turning abilities. Overall, a design approach based on modeling, simulation, and fabrication exemplified in this versatile robot represents a route to efficiently engineer complex biological machines with adaptive functionalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aisy.202000237","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T03:28:28Z","timestamp":1611890908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Computationally Assisted Design and Selection of Maneuverable Biological Walking Machines"],"prefix":"10.1002","volume":"3","author":[{"given":"Jiaojiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"Holonyak Micro and Nanotechnology Laboratory University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junehu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Material Science and Engineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insu","family":"Park","sequence":"additional","affiliation":[{"name":"Holonyak Micro and Nanotechnology Laboratory University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evin","family":"Kilicarslan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Holonyak Micro and Nanotechnology Laboratory University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"Department of Material Science and Engineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"Holonyak Micro and Nanotechnology Laboratory University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"Carle Illinois College of Medicine University of Illinois Urbana-Champaign  Champaign IL 61801 USA"},{"name":"Carl R. Woese Institute for Genomic Biology University of Illinois Urbana-Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2129-379X","authenticated-orcid":false,"given":"Mattia","family":"Gazzola","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"National Center for Supercomputing Applications University of Illinois Urbana-Champaign  Urbana IL 61801 USA"},{"name":"Carl R. 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