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Nevertheless, the conventional sensor systems made of rigid, bulky components cannot provide a reliable, conformal interface for accurate, continuous measurements of the epidermal physiological signals. Herein, a skin\u2010interfaced, multifunctional epidermal sensor patch with characteristics of mechanical softness, large stretchability, and wearable conformability for multimodal measurements of sEMG signals and associated skin deformations from various muscle activities and joint motions is reported. The sensor patch features two pairs of stretchable sEMG electrodes and two thin, miniaturized strain sensors, which are connected by stretchable filamentary serpentine interconnects in an open\u2010meshed structure. Experimental and computational studies reveal the design and operation of the sensor patch, which exhibit stable and repetitive performance even under a 30% stretching strain level. Demonstrations of the sensor patch on the wrist for simple sign language recognition and on the lower back for the flexion\u2010relaxation phenomenon illustrate its potential for the comprehensive assessment of the muscle activities and related motions of muscle joints.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202100031","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T14:29:52Z","timestamp":1625840992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Stretchable, Multifunctional Epidermal Sensor Patch for Surface Electromyography and Strain Measurements"],"prefix":"10.1002","volume":"3","author":[{"given":"Chengjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengming","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Sports Science Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggen","family":"Du","sequence":"additional","affiliation":[{"name":"Tuina Department Zhejiang Provincial Hospital of Chinese Medicine  Hangzhou 310006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Sports Science Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-9429","authenticated-orcid":false,"given":"Jizhou","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics and Soft Matter Research Center Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University  Hangzhou 310027 China"},{"name":"State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"e_1_2_8_2_1","volume":"6","author":"Liu H.","year":"2020","journal-title":"Microsyst. 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