{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:13:41Z","timestamp":1791630821641,"version":"4.3.4"},"reference-count":321,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Intelligent Systems"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Due to the difficulty of targeting systemically delivered therapeutics for cancer, interest has grown in exploiting biological agents to enhance tumor accumulation and mediate localized drug delivery. Equipped with onboard sensing and active motility, some cells respond to specific cues of the tumor microenvironment, making them ideal candidates for smart cancer therapy. Herein, recent progress and developments are presented on the use of four of the most promising cell\u2010based systems for tumor targeting and drug delivery\u2014immune cells, stem cells, platelets, and bacteria. Strategies to further enhance specificity at the tissue and cell level are discussed, including genetic engineering, chemical cell surface modification, and the use of external physical stimuli. With crucial ongoing efforts addressing the safety and efficacy of living intelligent therapeutics, a new era of cancer medicine is on the horizon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202100134","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T14:51:26Z","timestamp":1632927086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Engineering Cell\u2010Based Systems for Smart Cancer Therapy"],"prefix":"10.1002","volume":"4","author":[{"given":"Nima","family":"Mirkhani","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine Department of Health Sciences and Technology ETH Zurich  CH-8092 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinotenda","family":"Gwisai","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Department of Health Sciences and Technology ETH Zurich  CH-8092 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-1603","authenticated-orcid":false,"given":"Simone","family":"Schuerle","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Department of Health Sciences and Technology ETH Zurich  CH-8092 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja15.00681"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.139"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.93"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0070-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19322-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00175H"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3499"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.04.021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2934"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.11.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.09.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-control-053018-023803"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.11.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2020.100014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.645"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.614730"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27441"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020240"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2018.11.010"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.206128"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074942"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00508"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.4.661"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00074-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02739"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61067"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.10.009"},{"key":"e_1_2_7_34_1","unstructured":"C. C.Hedrick I.Malanchi Nat. Rev. Immunol.2021 https:\/\/doi.org\/10.1038\/s41577-021-00571-6 www.nature.com\/articles\/s41577-021-00571-6?proof=t#citeas."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2705"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00188"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24859"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10138"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.005"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.014"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01516997"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.035899"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13862"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.026"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1032"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02302-5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.217"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.006"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.04.016"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.8078"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0398-328"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3223"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001294"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00026-1"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10755"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/35074122"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0007-y"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12624"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-019-0003-0"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051848"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25492"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25501"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1970.tb00347.x"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02932"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240309797"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1128"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0013"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038833"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.05.004"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2469"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-025098"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1703"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.10.1557"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1241"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.9.3385"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000294"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12179"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.23"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.02.022"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402097"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28960"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8085637"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.329"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.071"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.05.035"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.108"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086652"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10475"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051060"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.03.010"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.14"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9332-4"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1874"},{"key":"e_1_2_7_97_1","volume":"34","author":"Li W.","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt221"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.03.005"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2004.03.007"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0943"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3997"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051921"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2750"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.04.032"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1247"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-176198"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0486"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108625"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.13"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.01.001"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00297"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1830"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.12.009"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047856"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249585"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9677-x"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01805"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2016.08.001"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00013"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-453498"},{"key":"e_1_2_7_123_1","doi-asserted-by":"crossref","unstructured":"N.Ortiz-Otero Z.Mohamed M. R.King inPlatelet-Based Drug Delivery for Cancer Applications(Eds:C.Dong N.Zahir K.Konstantopoulos) Biomechanics in Oncology. Advances in Experimental Medicine and Biology vol. 1092 Springer Cham2018 pp.235\u2013251.","DOI":"10.1007\/978-3-319-95294-9_12"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.002"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110352"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2007.04.005"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.10.012"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1001-1118"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.024"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3603"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay4860"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01209121"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509096346"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706013"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(02)00235-1"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.10.012"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.01.006"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-531582"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2010.12.001"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411082111"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.447"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.1.27"},{"key":"e_1_2_7_143_1","first-page":"1713","volume":"143","author":"Philippe C.","year":"1993","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1872"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00066"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.05.008"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-010-9353-9"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05095-8"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85086"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3164"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.005"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201800064"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1524"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/frobt.2018.00097"},{"key":"e_1_2_7_155_1","doi-asserted-by":"crossref","unstructured":"J. P.Armitage Encycl. Life Sci.2007 https:\/\/doi.org\/10.1002\/9780470015902.a0000340.pub2.","DOI":"10.1002\/9780470015902.a0000340.pub2"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02383.x"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.11.008"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161737"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.12.011"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000084"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.53.1.103"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1119\/1.10903"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/245380a0"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NR32554C"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219831110"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583508004691"},{"key":"e_1_2_7_167_1","first-page":"473","volume":"15","author":"Malmgren R. A.","year":"1955","journal-title":"Cancer Res."},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1006\/anae.1998.0161"},{"key":"e_1_2_7_169_1","unstructured":"T.Kimura K.Aoki T.Baba 1980 2061."},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.02.005"},{"key":"e_1_2_7_171_1","doi-asserted-by":"crossref","unstructured":"S.Taniguchi Y.Shimatani M.Fujimori in (Ed.:R.M.Hoffman) Springer New York NY 2016 pp.49\u201360.","DOI":"10.1007\/978-1-4939-3515-4_5"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3627"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2618"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib00091a"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.206"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652310790945575"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2984"},{"key":"e_1_2_7_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt937"},{"key":"e_1_2_7_180_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406242101"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00016"},{"key":"e_1_2_7_182_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006692"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0297-0"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-8-11"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21785"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2017.11.003"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-012-9696-x"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0018036"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9050102"},{"key":"e_1_2_7_190_1","doi-asserted-by":"crossref","unstructured":"D. A.Bazylinski D.Trubitsyn Magn. Nanoparticles Biosensing Med.2019 251.","DOI":"10.1017\/9781139381222.009"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr078258w"},{"key":"e_1_2_7_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2012.04.002"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1177\/0278364908100924"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.1177\/0278364908104855"},{"key":"e_1_2_7_195_1","doi-asserted-by":"crossref","unstructured":"N.Mokrani O.Felfoul F. A.Zarreh M.Mohammadi R.Aloyz G.Batist S.Martel inAnnu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBC\u201910 2010 4371.","DOI":"10.1109\/IEMBS.2010.5627105"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.137"},{"key":"e_1_2_7_197_1","first-page":"1","volume":"31","author":"Xing J.","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR01892A"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-013-9794-4"},{"key":"e_1_2_7_200_1","first-page":"1","volume":"30","author":"Mirkhani N.","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav4803"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1177\/0278364913479412"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMAG.2014.2323940"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.1177\/0278364917728331"},{"key":"e_1_2_7_205_1","doi-asserted-by":"crossref","unstructured":"D.Loghin C.Tremblay S.Martel inInt. Conf. Manip. Autom. Robot. Small Scales MARSS 2016 2016 https:\/\/doi.org\/10.1109\/MARSS.2016.7561739.","DOI":"10.1109\/MARSS.2016.7561739"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.005"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b03207"},{"key":"e_1_2_7_208_1","first-page":"1","volume":"2007473","author":"Buss M. T.","year":"2021","journal-title":"Adv. Mater."},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC00707G"},{"key":"e_1_2_7_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.0c00286"},{"key":"e_1_2_7_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39755"},{"key":"e_1_2_7_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9009"},{"key":"e_1_2_7_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.09.076"},{"key":"e_1_2_7_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38395"},{"key":"e_1_2_7_215_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00114"},{"key":"e_1_2_7_216_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_7_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2009.02.094"},{"key":"e_1_2_7_218_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2752721"},{"key":"e_1_2_7_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08068"},{"key":"e_1_2_7_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.008"},{"key":"e_1_2_7_221_1","first-page":"1","volume":"29","author":"Chu D.","year":"2017","journal-title":"Adv. Mater."},{"key":"e_1_2_7_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.168"},{"key":"e_1_2_7_223_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b01979"},{"key":"e_1_2_7_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000411"},{"key":"e_1_2_7_225_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.25613"},{"key":"e_1_2_7_226_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2035"},{"key":"e_1_2_7_227_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2743"},{"key":"e_1_2_7_228_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10024"},{"key":"e_1_2_7_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90502-X"},{"key":"e_1_2_7_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.36"},{"key":"e_1_2_7_231_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103849"},{"key":"e_1_2_7_232_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-711903"},{"key":"e_1_2_7_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.24"},{"key":"e_1_2_7_234_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524155113"},{"key":"e_1_2_7_235_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524193113"},{"key":"e_1_2_7_236_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316595"},{"key":"e_1_2_7_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.32"},{"key":"e_1_2_7_238_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0231"},{"key":"e_1_2_7_239_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006597"},{"key":"e_1_2_7_240_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0008"},{"key":"e_1_2_7_241_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9689-9"},{"key":"e_1_2_7_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2459"},{"key":"e_1_2_7_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.011"},{"key":"e_1_2_7_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.012"},{"key":"e_1_2_7_245_1","doi-asserted-by":"publisher","DOI":"10.1021\/sb500252a"},{"key":"e_1_2_7_246_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474098"},{"key":"e_1_2_7_247_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.16135"},{"key":"e_1_2_7_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.008"},{"key":"e_1_2_7_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.01.039"},{"key":"e_1_2_7_250_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9464"},{"key":"e_1_2_7_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.022"},{"key":"e_1_2_7_252_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805557"},{"key":"e_1_2_7_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900582"},{"key":"e_1_2_7_254_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701093"},{"key":"e_1_2_7_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.54"},{"key":"e_1_2_7_256_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_7_257_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201701021"},{"key":"e_1_2_7_258_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b00495"},{"key":"e_1_2_7_259_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00218E"},{"key":"e_1_2_7_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.040"},{"key":"e_1_2_7_261_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0513-z"},{"key":"e_1_2_7_262_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b23632"},{"key":"e_1_2_7_263_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00015H"},{"key":"e_1_2_7_264_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM01556B"},{"key":"e_1_2_7_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.05.037"},{"key":"e_1_2_7_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.048"},{"key":"e_1_2_7_267_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b11371"},{"key":"e_1_2_7_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.08.010"},{"key":"e_1_2_7_269_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5447"},{"key":"e_1_2_7_270_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4181"},{"key":"e_1_2_7_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.011"},{"key":"e_1_2_7_272_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.0c00238"},{"key":"e_1_2_7_273_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.7b00455"},{"key":"e_1_2_7_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.06.003"},{"key":"e_1_2_7_275_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_7_276_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn202399w"},{"key":"e_1_2_7_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.015"},{"key":"e_1_2_7_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.025"},{"key":"e_1_2_7_279_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1415"},{"key":"e_1_2_7_280_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-159541"},{"key":"e_1_2_7_281_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-018-9651-4"},{"key":"e_1_2_7_282_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1097-1"},{"key":"e_1_2_7_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_7_284_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16871"},{"key":"e_1_2_7_285_1","volume":"1","author":"Wang C.","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"e_1_2_7_286_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd7614"},{"key":"e_1_2_7_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.036"},{"key":"e_1_2_7_288_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02321"},{"key":"e_1_2_7_289_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2011.10"},{"key":"e_1_2_7_290_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2013.86"},{"key":"e_1_2_7_291_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4855"},{"key":"e_1_2_7_292_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.48.3.199-221.1984"},{"key":"e_1_2_7_293_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1130651"},{"key":"e_1_2_7_294_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.11432"},{"key":"e_1_2_7_295_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01036.x"},{"key":"e_1_2_7_296_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000739"},{"key":"e_1_2_7_297_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097418"},{"key":"e_1_2_7_298_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1342025"},{"key":"e_1_2_7_299_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.12371"},{"key":"e_1_2_7_300_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1790"},{"key":"e_1_2_7_301_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.149"},{"key":"e_1_2_7_302_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b00262"},{"key":"e_1_2_7_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2015.09.034"},{"key":"e_1_2_7_304_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01581"},{"key":"e_1_2_7_305_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211287110"},{"key":"e_1_2_7_306_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801309"},{"key":"e_1_2_7_307_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn5011304"},{"key":"e_1_2_7_308_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902626"},{"key":"e_1_2_7_309_1","first-page":"4537","volume":"57","author":"Pawelek J. M.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_7_310_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.1996.11.145"},{"key":"e_1_2_7_311_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16602-0"},{"key":"e_1_2_7_312_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30591"},{"key":"e_1_2_7_313_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.4.1157-1163.1994"},{"key":"e_1_2_7_314_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26006"},{"key":"e_1_2_7_315_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.076"},{"key":"e_1_2_7_316_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.188"},{"key":"e_1_2_7_317_1","first-page":"1","volume":"2","author":"Yu B.","year":"2012","journal-title":"Sci. Rep."},{"key":"e_1_2_7_318_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.9.2951"},{"key":"e_1_2_7_319_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2012.71"},{"key":"e_1_2_7_320_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax0876"},{"key":"e_1_2_7_321_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0498-z"},{"key":"e_1_2_7_322_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820824116"}],"container-title":["Advanced Intelligent Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aisy.202100134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aisy.202100134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aisy.202100134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:39:17Z","timestamp":1759880357000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/aisy.202100134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":321,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/aisy.202100134"],"URL":"https:\/\/doi.org\/10.1002\/aisy.202100134","archive":["Portico"],"relation":{},"ISSN":["2640-4567","2640-4567"],"issn-type":[{"value":"2640-4567","type":"print"},{"value":"2640-4567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]},"assertion":[{"value":"2021-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100134"}}