{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:04:16Z","timestamp":1784333056674,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFE0124400"],"award-info":[{"award-number":["2017YFE0124400"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFC0909000"],"award-info":[{"award-number":["2017YFC0909000"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFF0703500"],"award-info":[{"award-number":["2021YFF0703500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFA0910104"],"award-info":[{"award-number":["2021YFA0910104"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771983"],"award-info":[{"award-number":["81771983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971771"],"award-info":[{"award-number":["81971771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["19QA1404800"],"award-info":[{"award-number":["19QA1404800"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013285","name":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Intelligent Systems"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>A number of recently developed mass spectrometry (MS)\u2010based metabolic fingerprinting analyses are promoting metabolic analysis systems into practical clinical applications, including but not limited to disease diagnosis. Herein, recent cutting\u2010edge research on mass spectrometry\u2010based metabolic fingerprinting analytical methodology and clinical applications are described. These developments resolve challenges regarding the practical clinical applications of MS\u2010based metabolic fingerprinting analysis systems, such as rapid signal readout, high throughput and direct MS analysis, and intelligent data mining of complex biological samples.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202100191","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:53:02Z","timestamp":1642985582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Emerging Applications of Mass Spectrometry\u2010Based Metabolic Fingerprinting in Clinics"],"prefix":"10.1002","volume":"4","author":[{"given":"Jing","family":"Cao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering and Institute of Medical Robotics Shanghai Jiao Tong University  Shanghai 200030 P. R. China"},{"name":"Department of Biomedical Engineering Faculty of Engineering National University of Singapore  Singapore 117583 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering and Institute of Medical Robotics Shanghai Jiao Tong University  Shanghai 200030 P. R. China"},{"name":"Division of Cardiology Renji Hospital School of Medicine Shanghai Jiao Tong University  160 Pujian Road Shanghai 200127 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering National University of Singapore  Singapore 117583 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-1965","authenticated-orcid":false,"given":"Kun","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering and Institute of Medical Robotics Shanghai Jiao Tong University  Shanghai 200030 P. R. China"},{"name":"Division of Cardiology Renji Hospital School of Medicine Shanghai Jiao Tong University  160 Pujian Road Shanghai 200127 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20108"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00220-4"},{"key":"e_1_2_7_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200077"},{"key":"e_1_2_7_2_4","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00546"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700335d"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307429"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.9.1243"},{"key":"e_1_2_7_3_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913065"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08985C"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-019-02349-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b602376m"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.124"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-017-0014-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-1258-2_1","volume-title":"Mass Spectrometry in Metabolomics: Methods and Protocols","author":"Gowda G. A. N.","year":"2014"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200063"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201108888"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007978"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000906"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.016"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.053"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916960117"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.50"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.375"},{"key":"e_1_2_7_12_3","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.335"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00298.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00580-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0845-2"},{"key":"e_1_2_7_15_1","first-page":"92","volume":"1","author":"Worley B.","year":"2013","journal-title":"Curr. Metabolomics"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.101"},{"key":"e_1_2_7_17_1","first-page":"581","volume":"112","author":"Perez-Enciso M.","year":"2003","journal-title":"Hum. Genet."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci034160g"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2005.00503.x"},{"key":"e_1_2_7_20_1","first-page":"1202","volume":"45","author":"Lan L.","year":"2010","journal-title":"Build. Sci."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17347-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2019.08.014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202001001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.636917"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001135"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105478"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002021"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101333"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026796"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18646"},{"key":"e_1_2_7_29_3","doi-asserted-by":"publisher","DOI":"10.1021\/ac8020455"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09329-0"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01390-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0404-8"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA09894H"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1291-3"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac101283x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121043"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b05598"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.0c00452"}],"container-title":["Advanced Intelligent Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aisy.202100191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aisy.202100191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aisy.202100191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T21:25:26Z","timestamp":1759872326000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/aisy.202100191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,23]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/aisy.202100191"],"URL":"https:\/\/doi.org\/10.1002\/aisy.202100191","archive":["Portico"],"relation":{},"ISSN":["2640-4567","2640-4567"],"issn-type":[{"value":"2640-4567","type":"print"},{"value":"2640-4567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,23]]},"assertion":[{"value":"2021-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100191"}}