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The proposed patch has excellent adhesion to the gastrointestinal tract and contains anticancer drug doxorubicin and magnetic nanoparticles. This enables hyperthermia and the controlled release of the loaded drug under an alternating magnetic field (AMF). In addition, it can be delivered to multiple intestinal target lesions using a magnetically actuated capsule. Characteristic analyses of the proposed patch are performed, such as morphology, adhesion force measurement with intestine, temperature change under an AMF, and drug release. The feasibility of the patch delivery into the gastrointestinal tract is verified through locomotion performance tests and ex vivo patch delivery experiments using a magnetically actuated capsule. Finally, through an in vitro therapeutic effect test, the death of tumor cells using the proposed patch is confirmed. As a result, the possibility that the multiple mucoadhesive patches can be delivered to target lesions in a digestive tract through a magnetically actuated capsule and can treat the lesions through hyperthermia and active drug release using an AMF stimulation is verified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202100203","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T03:48:50Z","timestamp":1642564130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Drug\u2010Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability"],"prefix":"10.1002","volume":"4","author":[{"given":"Jihun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-in","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Bang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine and Yonsei Institute of Gastroenterology Yonsei University College of Medicine  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-897X","authenticated-orcid":false,"given":"Sukho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12061"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6457-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(03)00095-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200007000-00008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-1433.2004.02985.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e3181f90f0c"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03220.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.084"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3174"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0598-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2020.09.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3bm00004d"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00174J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200464x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605552103"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.11.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.am.20200901.11"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.08.043"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/la3025414"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.010"},{"key":"e_1_2_8_24_1","first-page":"1","volume":"24","author":"Quan W. 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