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Driven by the great versatility of the emerging artificial intelligence, machine\u2010learning\u2010supported bio\u2010integrated intelligent sensing system (BISS) is capable of achieving data processing and intelligent recognition while conducting multimodal human\u2010centered sensing; such facilitated systems capitalize the benefits of both bioelectronics and supporting algorithm, enabling accurate physiological\/somatosensory recognition at the cost of certain computing resources. Herein, an overview of recent progress in BISS is presented, with an emphasis on high\u2010tech applications enabled by innovations in combining flexible bioelectronic sensors with supporting algorithmic systems. The main applications can be divided into three categories, including implantable, skin\u2010mounted, and wearable BISS, which have different requirements for materials, fabrication methods, and algorithms, respectively. 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