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While these digital medicine technologies offer the potential to transform and revolutionize health care, many are at risk of stalling and remaining in the pilot stage, known as \u201cpilotitis,\u201d thus never reaching true potential. Therefore, overcoming \u201cpilotitis\u201d to increase the uptake of digital medicine technologies is a global concern. To date, several authors have proposed solutions to overcome various barriers owing to the \u201cpilotitis\u201d of digital medicine technologies, such as regulatory frameworks and patients\u2019 data ownership; however, many areas require further consideration. This perspective piece identifies three barriers to the adoption and implementation of digital medicine technologies and proposes approaches for how to overcome them. Addressing such barriers may provide a pathway to success for digital medicine technologies to improve patient outcomes and increase the efficiency of healthcare delivery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aisy.202200056","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T06:11:25Z","timestamp":1653545485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Overcoming Pilotitis in Digital Medicine at the Intersection of Data, Clinical Evidence, and Adoption"],"prefix":"10.1002","volume":"4","author":[{"given":"Mathias","family":"Egermark","sequence":"first","affiliation":[{"name":"The N.1 Institute for Health (N.1) National University of Singapore  Singapore 117456 Singapore"},{"name":"Department of Biomedical Engineering College of Design and Engineering National University of Singapore  Singapore 117583 Singapore"},{"name":"The Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore 117456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Blasiak","sequence":"additional","affiliation":[{"name":"The N.1 Institute for Health (N.1) National University of Singapore  Singapore 117456 Singapore"},{"name":"Department of Biomedical Engineering College of Design and Engineering National University of Singapore  Singapore 117583 Singapore"},{"name":"The Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore 117456 Singapore"},{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore 117600 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Remus","sequence":"additional","affiliation":[{"name":"The N.1 Institute for Health (N.1) National University of Singapore  Singapore 117456 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