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However, the sensitivity and response time of most sensors require further improvement to detect subtle strains related to human bodies. Herein, an ultrasensitive flexible optical sensor with fast response time has been built based on a microfiber coupler encapsulated in polydimethylsiloxane. Benefiting from dramatic change of coupling ratio of the microfiber coupler under weak strain, this flexible strain sensor exhibits ultrahigh strain sensitivity (gauge factor, GF\u2009=\u2009900), low detection limit (0.001%), ultrafast response time (&lt;0.167\u2009ms), wide sensing range (0.45%), and superior durability and stability (&gt;10\u2009000\u2009cycles). Real\u2010time capturing and recognizing of respiration, broadband sound signals, and pulse waves at different sites of human body have been demonstrated based on this highly sensitive microfiber coupler sensor. Moreover, simultaneous detection of the wrist pulse and human voice has been achieved based on the frequency division multiplexing technology. 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