{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:02:55Z","timestamp":1782255775123,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Intelligent Systems"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Surface microrollers have emerged as a promising microrobotic platform for navigation in the circulatory system as future drug\/gene delivery applications. The circulatory system comprises various vessels with different dimensions, blood flow velocities, and flow regimes. Therefore, the performance of surface microrollers would vary in blood vessels. Herein, the performance of surface microrollers, with diameters between 5 and 50\u2009\u03bcm, inside vessels of the systemic circulation including veins, venules, capillaries, arterioles, and arteries is investigated with computational fluid dynamics simulations. The simulation environment consists of a simplified fluid with the viscosity and density of blood, without red blood cells, in a cylindrical pipe. The microrollers demonstrate successful upstream locomotion ability in veins and partially in arteries but fail to perform in smaller blood vessels due to significant confinement and flow effects. Overall, the results presented here establish a preliminary result for the future in\u2009vivo use of surface microrollers.<\/jats:p>","DOI":"10.1002\/aisy.202300099","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T02:56:21Z","timestamp":1686020181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Microrobotic Locomotion in Blood Vessels: A Computational Study on the Performance of Surface Microrollers in the Cardiovascular System"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-2307","authenticated-orcid":false,"given":"Ugur","family":"Bozuyuk","sequence":"first","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  70569 Stuttgart Germany"},{"name":"Institute for Biomedical Engineering ETH Zurich  Zurich 8092 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakancan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  70569 Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-3854","authenticated-orcid":false,"given":"Metin","family":"Sitti","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  70569 Stuttgart Germany"},{"name":"Institute for Biomedical Engineering ETH Zurich  Zurich 8092 Switzerland"},{"name":"School of Medicine and School of Engineering Ko\u00e7 University  Istanbul 34450 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aba5726"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022090118"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1063\/5.0072842"},{"key":"e_1_2_9_2_4","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm9132"},{"key":"e_1_2_9_2_5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109741"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-010510-103409"},{"key":"e_1_2_9_4_1","volume-title":"Handbook of Hemorheology and Hemodynamics","author":"Baskurt O. 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