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This task is challenging due to high sperm velocity, collision with other sperm cells, and changes in the imaging focus. Herein, a new model is proposed, which is based on a multilayer long short\u2010term memory (LSTM) network combined with linear extrapolation calculation, for predicting the future location of individual sperm cells based on their previous paths. The model is trained with a unique loss function, constructed from the predicted location and trajectory, and results in low mean location error predictions. The results are based on comparing different input sequences length, number of time frames ahead, and motility parameters of sperm cells. This model can provide faster and more accurate sperm motility predictions, better tracking, and aid automatic sperm capturing technologies.<\/jats:p>","DOI":"10.1002\/aisy.202300161","type":"journal-article","created":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T23:21:56Z","timestamp":1688944916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Location Prediction of Sperm Cells Using Long Short\u2010Term Memory Networks"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-4299","authenticated-orcid":false,"given":"Lioz","family":"Noy","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"}]},{"given":"Itay","family":"Barnea","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"}]},{"given":"Matan","family":"Dudaie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"}]},{"given":"Dotan","family":"Kamber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"}]},{"given":"Mattan","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"IVF Laboratory Meir Hospital  Kfar Saba 4428164 Israel"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-839X","authenticated-orcid":false,"given":"Natan T.","family":"Shaked","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"}]}],"member":"311","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.78430"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.614118"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199402000-00020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.10.2241"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-012-0126-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2228-7477.128436"},{"key":"e_1_2_8_10_1","first-page":"163","volume":"2019","author":"Qi S.","year":"2019","journal-title":"Int. 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