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Herein, 10 diagnostic models for 10 common types of cancer are developed by extreme gradient boosting, incorporating 66 laboratory parameters. The datasets consist of a retrospective cohort of 737\u2009503 training and 184\u2009012 validation cases, and a prospective cohort of 174\u2009894 cases for model testing. The areas under the curve of the 10 diagnostic models range from 0.763 to 0.993. Notably, the different models have varying numbers of identical parameters among the 66 test features. Additionally, SHapley Additive exPlanation analysis reveals that 54 nontumor markers contributed significantly to the models. Cosine similarity analysis and clustering analysis demonstrate that some of the 10 cancers share common pathophysiological characteristics. Feature\u2010based inference graph models are thus performed and infer relationships between nontumor index parameters and cancers with strong correlations. 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