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An eight\u2010neighborhood\u2010based method for increasing the localization accuracy of guidewire endpoint to improve the safety of interventional procedures is proposed herein. The proposed method includes two stages: 1) An improved U\u2010Net network is employed for segmenting the data of the guidewire to extract regions of interest containing guidewire endpoints with higher precision and to reduce interference from other anatomical structures and imaging artifacts. 2) The proposed method detects guidewire endpoints using the adjacent relationship between pixels in the eight\u2010neighborhood regions. This stage covers skeletonization extraction, removal of bifurcation points, and repair of fracture points. This study achieves mean pixel errors of 2.02 and 2.13\u2009pixels in an in\u2009vivo rabbit and porcine X\u2010ray fluoroscopy images, outperforming ten classic heatmap and regression methods, achieving state\u2010of\u2010the\u2010art detection results. The proposed method can also be applied to detect other tiny surgical instruments such as stents and balloons, while preserving the flexibility of the guidewire bending angle.<\/jats:p>","DOI":"10.1002\/aisy.202300687","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T07:09:34Z","timestamp":1704524974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Guidewire Endpoint Detection Based on Pixel\u2010Adjacent Relation during Robot\u2010Assisted Intravascular Catheterization: In Vivo Mammalian Models"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-3398","authenticated-orcid":false,"given":"Wenjing","family":"Du","sequence":"first","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"},{"name":"School of Computer Science University of Nottingham Ningbo China  199 Taikang East Road Ningbo 315100 China"}]},{"given":"Guanlin","family":"Yi","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"}]},{"given":"Olatunji Mumini","family":"Omisore","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"}]},{"given":"Wenke","family":"Duan","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"},{"name":"Academy for Engineering and Technology Fudan University  220 Handan Road Shanghai 200433 China"}]},{"given":"Xingyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"}]},{"given":"Toluwanimi","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering Southern University of Science and Technology  1088 Xueyuan Blvd., Nanshan District Shenzhen 518055 China"}]},{"given":"Boon\u2010Giin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Computer Science University of Nottingham Ningbo China  199 Taikang East Road Ningbo 315100 China"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  1068 Xueyuan Avenue, Shenzhen University Town Shenzhen 518055 China"}]}],"member":"311","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9783517"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.34133\/cbsystems.0042"},{"key":"e_1_2_8_5_1","unstructured":"P.Ambrosini D.Ruijters W. 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