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Simultaneous real\u2010time visualization and manipulation of microcarriers at any depth in the human body is far to be achieved even though one of each task has been successfully proven. Herein, a novel targeting strategy is proposed that employs field\u2010free region (FFR) scanning to guide microcarriers through multiple bifurcations within a predefined vessel network. The main challenge of this method lies on how, where, and when to activate FFR to steer a particle to a desired direction, regardless of its spatial feedback. To achieve it, first, a mathematical model of particle motion in a vessel network is developed to predict particle behaviors and positions. Subsequently, an optimization algorithm is formulated to place FFR well\u2010coordinated around each bifurcation at a designated moment. The established solution for targeting a magnetic microcarrier is preemptively evaluated through finite element simulations and then successfully implemented in in\u2009vitro multibranched vessels.<\/jats:p>","DOI":"10.1002\/aisy.202300700","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T15:28:35Z","timestamp":1713194915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Field\u2010Free Region Scanning\u2010Based Magnetic Microcarrier Targeting in Multibifurcation Vessels"],"prefix":"10.1002","volume":"6","author":[{"given":"Kim Tien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Korea Institute of Medical Microrobotics  Gwangju 61011 Korea"}]},{"given":"Hyeonwoo","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science &amp; Technology (DGIST)  Daegu 42988 Korea"}]},{"given":"Gwangjun","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Chosun University  Gwangju 61452 Korea"}]},{"given":"Seok\u2010Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Medical Microrobotics  Gwangju 61011 Korea"}]},{"given":"Eunpyo","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Chonnam National University  Gwangju 61186 Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-2661","authenticated-orcid":false,"given":"Jong\u2010Oh","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Institute of Medical Microrobotics  Gwangju 61011 Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-897X","authenticated-orcid":false,"given":"Sukho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science &amp; Technology (DGIST)  Daegu 42988 Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-4937","authenticated-orcid":false,"given":"Jayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Medical Microrobotics  Gwangju 61011 Korea"},{"name":"Department of Biosystems Engineering Chungbuk National University  Cheongju 28644 Korea"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-017-0004-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_2_10_4_1","first-page":"9824057","volume":"2022","author":"Li J.","year":"2022","journal-title":"Cyborg Bionic Syst."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.34133\/cbsystems.0004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2021.102509"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-00909-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102165"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TRO.2015.2489518"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.031"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.202000082"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-011-0332-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.10.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8110907"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.170873"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.202300052"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/24699322.2016.1236146"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2016.11.016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMAG.2014.2307271"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TRO.2010.2073030"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIE.2017.2782220"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2009.11.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCYB.2022.3199213"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.202200072"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9835014"},{"key":"e_1_2_10_27_1","first-page":"96","volume":"27","author":"W\u00e1ng Y. 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