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This study introduces the double\u2010layered metal\u2010organic\u2010frameworks (MOFs)\u2010based microswimmers for sustained dual\u2010drug delivery. These microswimmers are made up of ZIF\u20108 and MIL\u2010100, biocompatible MOFs, that can selectively adsorb two types of drugs. The MOFs increase the surface area of the microswimmers by \u22482.42 times, which greatly enhances drug adsorption, and improves hydrophilicity, which reduces adhesion for surface locomotion. Their biocompatibility and dual\u2010drug adsorption are verified through cell viability and drug\u2010loading tests. The microswimmers have remarkable versatility in loading different drug combinations (DHA\u2009+\u20095\u2010FU, CPT\u201011, or DOX), indicating the potential for adaptive therapy. They can inhibit cancer cells for up to 72\u2009h through the sustained release of dual drugs. In contrast, drug treatments without microswimmers only inhibit cell proliferation for 24\u2009h, leading to a significant rebound. 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