{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:22:03Z","timestamp":1778001723024,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00394"],"award-info":[{"award-number":["PI21\/00394"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI19\/00146"],"award-info":[{"award-number":["FI19\/00146"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021\u2010127296OB\u2010I00"],"award-info":[{"award-number":["PID2021\u2010127296OB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Intelligent Systems"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Pancreatic ductal adenocarcinoma (PDAC) poses a considerable diagnostic and therapeutic challenge due to the lack of specific biomarkers and late diagnosis. Early detection is crucial for improving prognosis, but current techniques are insufficient. An innovative approach based on differential scanning calorimetry (DSC) of blood serum samples, thermal liquid biopsy (TLB), combined with machine\u2010learning (ML) analysis, may offer a more efficient method for diagnosing PDAC. Serum samples from a cohort of 212 PDAC patients and 184 healthy controls are studied. DSC thermograms are analyzed using ML models. The generated models are built applying algorithms based on penalized regression, resampling, categorization, cross validation, and variable selection. The ML\u2010based model demonstrates outstanding ability to discriminate between PDAC patients and control subjects, with a sensitivity of 90% and an area under the ROC receiver operating characteristic curve of 0.83 in the training and test groups. Application of the model to an independent validation cohort of 113 PDAC patients confirms its robustness and utility as a diagnosis tool. The application of ML to serum TLB data emerges as a promising \u00a0methodology for early diagnosis, representing a significant advance for detecting and managing PDAC, envisaging a minimally invasive and more efficient methodology for identifying biomarkers.<\/jats:p>","DOI":"10.1002\/aisy.202400308","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T03:24:07Z","timestamp":1728357847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of a Machine\u2010Learning Model for Diagnosis of Pancreatic Cancer from Serum Samples Analyzed by Thermal Liquid Biopsy"],"prefix":"10.1002","volume":"7","author":[{"given":"Sonia","family":"Hermoso\u2010Dur\u00e1n","sequence":"first","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI) Joint Units IQFR\u2010CSIC\u2010BIFI, and GBsC\u2010CSIC\u2010BIFI Universidad de Zaragoza  50018 Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n)  50009 Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  28029 Madrid Spain"}]},{"given":"Nicolas","family":"Fraunhoffer","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, Equipe Lab\u00e9lis\u00e9e Ligue Nationale Contre le Cancer  13288 Marseille France"}]},{"given":"Judith","family":"Millastre\u2010Bocos","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa  50009 Zaragoza Spain"}]},{"given":"Oscar","family":"Sanchez\u2010Gracia","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Electr\u00f3nica y Comunicaciones Universidad de Zaragoza  50018 Zaragoza Spain"}]},{"given":"Pablo F.","family":"Garrido","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI) Joint Units IQFR\u2010CSIC\u2010BIFI, and GBsC\u2010CSIC\u2010BIFI Universidad de Zaragoza  50018 Zaragoza Spain"},{"name":"Department of Physics University of Oslo  0316 Oslo Norway"},{"name":"Center for Lifespan Changes in Brain and Cognition University of Oslo  0371 Oslo Norway"}]},{"given":"Sonia","family":"Vega","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI) Joint Units IQFR\u2010CSIC\u2010BIFI, and GBsC\u2010CSIC\u2010BIFI Universidad de Zaragoza  50018 Zaragoza Spain"}]},{"given":"\u00c1ngel","family":"Lanas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n)  50009 Zaragoza Spain"},{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa  50009 Zaragoza Spain"}]},{"given":"Juan","family":"Iovanna","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, Equipe Lab\u00e9lis\u00e9e Ligue Nationale Contre le Cancer  13288 Marseille France"},{"name":"Hospital de Alta Complejidad El Cruce  Florencio Varela Buenos Aires B1888 Argentina"},{"name":"University Arturo Jauretche  Florencio Varela Buenos Aires B1888 Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-4538","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Vel\u00e1zquez\u2010Campoy","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI) Joint Units IQFR\u2010CSIC\u2010BIFI, and GBsC\u2010CSIC\u2010BIFI Universidad de Zaragoza  50018 Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n)  50009 Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  28029 Madrid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Universidad de Zaragoza  50009 Zaragoza Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-1729","authenticated-orcid":false,"given":"Olga","family":"Abian","sequence":"additional","affiliation":[{"name":"Institute of Biocomputation and Physics of Complex Systems (BIFI) Joint Units IQFR\u2010CSIC\u2010BIFI, and GBsC\u2010CSIC\u2010BIFI Universidad de Zaragoza  50018 Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n)  50009 Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  28029 Madrid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Universidad de Zaragoza  50009 Zaragoza Spain"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143634"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.09.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2020.94845"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110869"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070677"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.med.2021.01.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4215"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6658"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084710"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2008.12.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.09.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200405866"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257601"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.119453"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14163884"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac202055m"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tca.2011.06.019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-013-2999-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-012-2468-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.007"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-013-3585-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0722-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-015-4642-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-016-5291-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-016-5495-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-016-5371-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tca.2018.02.014"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-020-09443-y"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-020-09442-z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2016.2970"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2010.09.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/OAMS.S40069"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.10.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186232"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186398"},{"key":"e_1_2_9_39_1","first-page":"0220765","volume":"14","author":"Rai S. N.","year":"2019","journal-title":"PLoS One"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10155135"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821229-5.00003-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu622"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194658"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2022.101097"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010885"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00491"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2018.03.001"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR01413F"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15112983"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15071952"}],"container-title":["Advanced Intelligent Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aisy.202400308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:24:15Z","timestamp":1759857855000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/aisy.202400308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/aisy.202400308"],"URL":"https:\/\/doi.org\/10.1002\/aisy.202400308","archive":["Portico"],"relation":{},"ISSN":["2640-4567","2640-4567"],"issn-type":[{"value":"2640-4567","type":"print"},{"value":"2640-4567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]},"assertion":[{"value":"2024-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400308"}}