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Significant efforts have been dedicated to the improvement and control of contraction force, going one step forward toward the automation of these biohybrid platforms. Herein, 3D\u2010bioengineered skeletal muscle tissues are integrated with organic transistor\u2010based sensors to define a soft bioactuator with real\u2010time force monitoring capabilities. The muscle tissue is electrically stimulated while the organic sensor ensures transduction of the exerted force into an electrical signal that allows direct monitoring of the bioactuator performance. Sensor calibration is carried out to define its sensitivity at different biasing conditions: as opposed to standard, two\u2010terminal piezoresistive devices, transistor\u2010based strain sensors show tunable sensitivity by acting on the voltage applied to a third terminal\n                    <jats:italic>\u2014<\/jats:italic>\n                    the gate. A complete evaluation of sensing performances is provided, demonstrating that real\u2010time monitoring is effective under different conditions, including stimulation signal frequency and chemical modulation of the bioactuator contraction, demonstrating its potential use as a drug testing platform. In the reported results, the way is paved for a complete exploitation of organic devices in soft robotic applications and to the development of novel biohybrid machines in bioengineering and biomedicine.\n                  <\/jats:p>","DOI":"10.1002\/aisy.202400407","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T03:11:32Z","timestamp":1728875492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010Time Force Monitoring of Electrically Stimulated 3D\u2010Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-1865","authenticated-orcid":false,"given":"Stefano","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering University of Cagliari  Piazza d\u2019Armi 09123 Cagliari 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