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However, interfacing rigid, nonstretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. Herein, an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network is developed, which can rapidly and robustly adhere electrochemical biosensors with biological tissues, enabling strain\u2010insensitive physiological monitoring. The electrical tissue adhesive achieves a high fracture toughness of up to 3000\u2009J\u2009m<jats:sup>\u22122<\/jats:sup>, a low Young's modulus of around 20\u2009kPa, superior stretchability up to 15 times its initial length, and an overall biosensor\u2010tissue interfacial toughness of up to 500\u2009J\u2009m<jats:sup>\u22122<\/jats:sup>. Using an electrochemical glucose sensor as one example, it is demonstrated that the electrical tissue adhesive can maintain resilient glucose sensing under various stress states and stretch levels. Additionally, the application of the electrical tissue adhesive for in\u2010situ monitoring of exercise and diet in subjects with various BMIs is demonstrated by measuring glucose concentration in sweat.<\/jats:p>","DOI":"10.1002\/aisy.202400697","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T08:37:52Z","timestamp":1730191072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrical Tissue Adhesives for Strain\u2010Insensitive In\u2010situ Biosensing"],"prefix":"10.1002","volume":"7","author":[{"given":"Tsz Hung","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Jiabin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Yijie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Yilin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Animal Science Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Camryn","family":"Anway","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Ruihao","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Natural Science Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Chuwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Zhaohan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Animal Science Michigan State University  East Lansing 48824 MI USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-493X","authenticated-orcid":false,"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing 48824 MI USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-9628","authenticated-orcid":false,"given":"Shaoting","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing 48824 MI USA"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16521"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35074-y"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9842"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-020-00280-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.02.006"},{"key":"e_1_2_8_3_2","first-page":"838","volume":"333","author":"Kim D.-H.","year":"2011","journal-title":"Sci. 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