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This article proposes a monolithic biohybrid flexure mechanism actuated by a bioengineered skeletal muscle tissue. The design leverages the contractile properties of a bioengineered skeletal muscle to produce a bending motion in a monolithic, tubular mechanism made of a soft and biocompatible silicone blend. This structure integrates two cylindrical pillars that facilitate force transmission from the bioengineered muscle tissue. Performance assessments reveal excellent contractile and stable behavior upon electrical stimulation, compared to current biohybrid actuation systems, with enhanced performance as the mechanism's internal and external diameters decrease. Finite\u2010element simulations further reveal distinct force\u2013displacement responses in mechanisms with different flexural rigidity. This innovative, scalable, and easy\u2010to\u2010fabricate design represents a significant step forward in the development of novel biohybrid machines.<\/jats:p>","DOI":"10.1002\/aisy.202400989","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:51:09Z","timestamp":1748339469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5677-594X","authenticated-orcid":false,"given":"Andrea","family":"Bartolucci","sequence":"first","affiliation":[{"name":"The BioRobotics Institute Scuola Superiore Sant\u2019Anna  56127 Pisa Italy"},{"name":"Department of Excellence in Robotics and AI Scuola Superiore Sant\u2019Anna  56127 Pisa 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