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However, industrial solutions mostly do not fit the needs of scientific institutions, such as cost efficiency, customizability, and flexibility in fast iteration cycles. This study presents a laboratory automation system that integrates affordable robotics and artificial intelligence (AI)\u2010driven functionalities in a modular architecture to address key challenges in research environments. The system uses a robotic arm and a large language model (LLM) as a lab assistant, enabling natural language interaction and task orchestration. In contrast to fully autonomous systems, this approach emphasizes a collaborative human\u2010in\u2010the\u2010loop model, ensuring adaptability and reducing reliance on artificial intelligence for task planning. Key innovations include meta\u2010tools for dynamic task recording and playback, low\u2010level information management to reduce cognitive load on the LLM, and AI\u2010assisted data reading for real\u2010time measurement extraction. The system's ability to automate complex workflows is validated in three experimental scenarios, involving sample preparation, error handling, and multi\u2010step measurements. The system demonstrates the ability to perform tasks with minimal user input while maintaining flexibility and adaptability to changing experimental conditions. The findings pave the way for the future of laboratory automation, where human and AI\u2010driven systems work seamlessly together in optimized scientific workflows.<\/jats:p>","DOI":"10.1002\/aisy.202401086","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T19:30:13Z","timestamp":1740339013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lowering the Entrance Hurdle for Lab Automation: An Artificial Intelligence\u2010Supported, Interactive Robotic Arm for Automated, Repeated Testing Procedures"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-9842","authenticated-orcid":false,"given":"Stefan","family":"Conrad","sequence":"first","affiliation":[{"name":"Plant Biomechanics Group Freiburg Botanic Garden of the University of Freiburg University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7897-1470","authenticated-orcid":false,"given":"Philipp","family":"Auth","sequence":"additional","affiliation":[{"name":"Plant Biomechanics Group Freiburg Botanic Garden of the University of Freiburg University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-8252","authenticated-orcid":false,"given":"Tom","family":"Masselter","sequence":"additional","affiliation":[{"name":"Plant Biomechanics Group Freiburg Botanic Garden of the University of Freiburg University of Freiburg  79104 Freiburg Germany"},{"name":"Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) University of Freiburg  79110 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2245-2636","authenticated-orcid":false,"given":"Thomas","family":"Speck","sequence":"additional","affiliation":[{"name":"Plant Biomechanics Group Freiburg Botanic Garden of the University of Freiburg University of Freiburg  79104 Freiburg Germany"},{"name":"Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) University of Freiburg  79110 Freiburg Germany"},{"name":"Cluster of Excellence livMatS FIT \u2013 Freiburg Center for Interactive Materials and Bioinspired Technologies University of Freiburg  79110 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.adm6991"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"F. 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