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Inspired by clinlabomics, a liquid biopsy method for the detection and identification of ten cancers is reported. By applying the blending ensemble learning method to clinical laboratory data, separate cancer detection and identification models are developed to construct an intelligence system, called clinlabomics assisted for cancer identification (CACI). The CACI is applied to 19\u2009199 individuals, including 9,047 noncancer patients in the control group and 10\u2009152 patients with 10 types of multiple cancers from Lanzhou University Second Hospital. In the external test cohort, the cancer detection model, based on 21 indices, exhibits a sensitivity of 90.39%, specificity of 82.41%, with an area under the curve (AUC) exceeding 0.9373 in distinguishing cancer from noncancer individuals. The cancer identification model, constructed using 34 top\u2010rank indices after feature extraction, achieves an overall accuracy of 72.57%. 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The results provide valuable guidance for physicians, enabling them to select more accurate testing indicators and assess disease risks with greater precision.<\/jats:p>","DOI":"10.1002\/aisy.202500247","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:35:14Z","timestamp":1752755714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinlabomics\u2010Enabled Blending Ensemble Learning for Low\u2010Cost Pan\u2010Cancer Detection and Classification Using Routine Clinical Laboratory Data"],"prefix":"10.1002","volume":"7","author":[{"given":"Bowen","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"},{"name":"School of Electronic Information and Communications Huazhong University of Science and Technology  Wuhan 430073 Hubei China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9372-9320","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lanzhou University Second Hospital  Lanzhou 730000 Gansu China"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"}]},{"given":"Zhaoqing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"}]},{"given":"Jiangpeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 Gansu China"}]},{"given":"Pengyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 Gansu China"}]},{"given":"Jiarui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"},{"name":"Department of Medical Affairs The Second Affiliated Hospital of Xuzhou Medical University  Xuzhou 221004 Jiangsu China"}]},{"given":"Dekui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lanzhou University Second Hospital  Lanzhou 730000 Gansu China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-4166","authenticated-orcid":false,"given":"Shuyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Information and Engineering Xuzhou Medical University  Xuzhou 221004 Jiangsu China"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12204"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3247"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21557"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.634316"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0380"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39486"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03000-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1043-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i38.6399"},{"key":"e_1_2_9_14_1","first-page":"1","volume":"2","author":"Eminaga O.","year":"2018","journal-title":"JCO Clin. 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