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The released secretory products were found in the form of discrete granules, with or without a perigranular membrane, in intercellular spaces, between the plasma membrane and the parenchymal basement membrane, in the perivascular space, in the endothelial cytoplasm, and in the lumen of capillaries. Vesicles containing material which resembled that in the perivascular space were observed in endothelial cells.<\/jats:p><jats:p>Interpretation of these observations has led to the proposal of the theory that secretory products of the adenohypophysis may be liberated from parenchymal cells in the following way: by fusion of the perigranular membrane with the plasma membrane (merocrine) or by the detachment of small processes containing secretory granules (\u201cmicroapocrine\u201d). It is further believed that the discharged products may be transported into circulation in three different manners: by diffusion of dissolved material through the fenestrated endothelium, by active transport of dissolved secretory products by the endothelial cells, or by active transport of intact secretory granules through the endothelial cytoplasm.<\/jats:p>","DOI":"10.1002\/aja.1001150202","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T03:51:22Z","timestamp":1109476282000},"page":"199-215","source":"Crossref","is-referenced-by-count":16,"title":["Morphologic observations concerning the release and transport of secretory products in the adenohypophysis"],"prefix":"10.1002","volume":"115","author":[{"given":"Hernando","family":"Salazar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy R.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001120102"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2164-0947.1961.tb01361.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331976101200704"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-54-5-516"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-55-6-857"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.3.2.319"},{"key":"e_1_2_1_8_1","first-page":"231","article-title":"Electron microscopic observations on the secretory processes in prolactin cells of the mouse anterior pituitary (Abstract)","volume":"145","author":"Garwood V. 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