{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:17:24Z","timestamp":1756991844920},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":13366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mesometrial arteries of pregnant guinea pigs are not mere blood conducting channels. Instead they are dynamic in nature. The cells forming the intima and media exhibited significant structural modifications during pregnancy. The endothelial cells became hypertrophied and attenuated. Their cytoplasm showed an increase in the amount of ribosomes, rough endoplasmic reticulum and lysosome\u2010like bodies during pregnancy. Dense bodies that were often closely associated with the Golgi apparatus were seen in pregnant animals. These bodies exhibited a graduation in size within each cell and were thought to be the precursors of the lysosome\u2010like bodies. Similar structures were also seen in smooth muscle cells of the mesometrial arteries of pregnant animals.<\/jats:p><jats:p>The endothelium of these arteries was often discontinuous in full term pregnant animals. In that case, the underlying smooth muscl4 cells provided the lining surface. Irrespective of which type of cells formed the lumen of these arteries, they became coated with a \u201cfuzzy\u201d layer which specifically stained intensely with phosphotungstic acid, suggesting that this layer might be a mucoprotein. The smooth muscle cell of the arterial media also became hypertrophied during pregnancy. The cytoplasm exhibited a gradual increase in free ribosomes and rough endoplasmic reticulum, mitochondria and microtubules throughout pregnancy. During the latter half of pregnancy many smooth muscle cells developed extensive amounts of smooth endoplasmic reticulum whose vesicles often were filled with an electron opaque secretory material. It is suggested that the development of unusually large quantities of smooth endoplasmic reticulum might be associated with steroid metabolism. Unusually thick basement membranes were formed around the modified smooth muscle cells of full term pregnant animals and the surfaces of these cells often exhibited large numbers of microvilli. The microvilli seemed to disrupt the continuous patterns of the basement membrane.<\/jats:p>","DOI":"10.1002\/aja.1001230108","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T15:00:13Z","timestamp":1109430013000},"page":"165-193","source":"Crossref","is-referenced-by-count":9,"title":["An electron microscopic study of uterine arteries during pregnancy"],"prefix":"10.1002","volume":"123","author":[{"given":"Ernest N.","family":"Albert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Pease","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001200311"},{"key":"e_1_2_1_3_1","first-page":"204","article-title":"An electron microscopic study of uterine arteries during pregnancy","volume":"157","author":"Albert E.","year":"1967","journal-title":"(Abst.) 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