{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:50:26Z","timestamp":1761058226118,"version":"build-2065373602"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":3474,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tenascin\u2010X (TN\u2010X) is the newest member of the tenascin family of extracellular matrix proteins and it is highly expressed in muscular tissues during development. To gain insight into the possible functions of TN\u2010X during development, we evaluated its expression in the rat embryo. Using an 800 bp cDNA encoding the fibrinogen\u2010like domain of TN\u2010X, we show that TN\u2010X expression begins in migrating cells of the epicardium in the E12 heart. The epicardium provides progenitors of fibrous and vascular tissue to the developing heart. After the epicardium is complete, TN\u2010X is expressed in the sub\u2010epicardial space in association with developing blood vessels, and later by non\u2010myocytes dispersed through the myocardial wall. A similar pattern of TN\u2010X expression, first in connective tissue surrounding muscle, and then by a subset of cells within muscle, was seen in para\u2010axial, body wall, craniofacial, and appendicular muscle. This pattern suggests a role in connective tissue cell migration and late muscle morphogenesis. TN\u2010X is also highly expressed in the interdigital space at E15 and surrounding developing tendons, suggesting an additional role in cell fate determination. Although the pattern of TN\u2010X expression is distinct from that of tenascin C, they are frequently expressed in close proximity. Indirect genetic evidence in humans suggests an essential function for TN\u2010X, and the pattern of TN\u2010X expression in heart, skeletal muscle, and limb is consistent with this hypothesis. \u00a91995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/aja.1002030411","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T20:52:47Z","timestamp":1109451167000},"page":"491-504","source":"Crossref","is-referenced-by-count":81,"title":["Embryonic expression of tenascin\u2010X suggests a role in limb, muscle, and heart development"],"prefix":"10.1002","volume":"203","author":[{"given":"Grant H.","family":"Burch","sequence":"first","affiliation":[]},{"given":"Melanie A.","family":"Bedolli","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"McDonough","sequence":"additional","affiliation":[]},{"given":"Stephen M.","family":"Rosenthal","sequence":"additional","affiliation":[]},{"given":"James","family":"Bristow","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53809-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240280302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1016\/S0021-9258(18)31473-X","article-title":"Abundant adrenal\u2010specific transcription of the human P450c21A \u201cpseudogene","volume":"268","author":"Bristow J.","year":"1993","journal-title":"J. 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