{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:23:05Z","timestamp":1767842585423,"version":"3.49.0"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T00:00:00Z","timestamp":1168473600000},"content-version":"vor","delay-in-days":7315,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The reproductive toxicology of 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (TCDD) has been studied in animal models and in human populations. In animals, TCDD has a range of toxic effects on organs of the reproductive system in males and females, on hormone biochemistry, and on embryo\u2010fetal development. These effects may involve in part an identified intracellular TCDD receptor and its association with the induction of microsomal cytochrome P\u2010450\u2010dependent monooxygenases in many organs. TCDD treatment increases activity of monooxygenase enzyme in liver and gonads of treated animals, but unlike other polycyclic aromatic hydrocarbons that are monooxygenase inducers, TCDD is not cytotoxic to any population of oocytes in the mature female mouse. Epidemiological studies of TCDD reproductive toxicity have been limited in design. There are some reports of adverse effects in the Seveso population and in children born to American veterans presumed to have been exposed to TCDD in Agent Orange during the Vietnam war. Occupational cohorts have not been found to show such paternally mediated effects of TCDD exposure.<\/jats:p>","DOI":"10.1002\/ajim.4700110203","type":"journal-article","created":{"date-parts":[[2007,4,16]],"date-time":"2007-04-16T22:19:16Z","timestamp":1176761956000},"page":"131-144","source":"Crossref","is-referenced-by-count":18,"title":["Experimental and clinical studies on the reproductive toxicology of 2,3,7,8\u2010tetrachlorodibenzo\u2010<i>p<\/i>\u2010dioxin"],"prefix":"10.1002","volume":"11","author":[{"given":"Ellen K.","family":"Silbergeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Mattison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-109-27100"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91955-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01685454"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(77)90361-6"},{"issue":"22","key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1001\/jama.1979.03300220011002","article-title":"Symptoms in Vietnam veterans exposed to Agent Orange","volume":"242","author":"Bogen G","year":"1979","journal-title":"JAMA"},{"key":"e_1_2_1_7_1","first-page":"3172","article-title":"Tissue distribution of the receptor for 2,3,7,8\u2010TCDD in the rat","volume":"39","author":"Carlstedt\u2010Duke JMB","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770050404"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90282-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90206-6"},{"key":"e_1_2_1_11_1","first-page":"275","volume-title":"Public Health Risks of the Dioxins","author":"Dean J","year":"1984"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1984.tb108096.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-452810-9.50012-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jama.1984.03350070021017","article-title":"Vietnam veterans' risks for fathering babies with birth defects","volume":"252","author":"Erickson JD","year":"1984","journal-title":"JAMA"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91967-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602538209029984"},{"key":"e_1_2_1_17_1","first-page":"90","article-title":"Cytosolic receptor for 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin. 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